PMID- 19223156
OWN - NLM
STAT- MEDLINE
DCOM- 20090605
LR  - 20220409
IS  - 1873-7862 (Electronic)
IS  - 0924-977X (Linking)
VI  - 19
IP  - 5
DP  - 2009 May
TI  - Plasma Brain-Derived Neurotrophic Factor in treatment-resistant depressed 
      patients receiving electroconvulsive therapy.
PG  - 349-55
LID - 10.1016/j.euroneuro.2009.01.002 [doi]
AB  - There is an increasing evidence that the Brain-Derived Neurotrophic Factor (BDNF) 
      could be involved in the mode of action of antidepressants and, perhaps, of ECT. 
      This study aimed to investigate whether the clinical course of 
      medication-resistant depressed patients following a course of ECT might be 
      associated with changes of plasma BDNF concentrations. Our findings showed that 
      at T0 (baseline) plasma BDNF levels of patients were significantly lower than 
      those of control subjects, and that at T2 (after ECT) were significantly 
      increased in parallel with the decrease of the Hamilton Rating Scale for 
      Depression (HRSD) total score. However, only remitter patients who showed higher 
      baseline BDNF levels than non-remitters reached normalized BDNF levels after ECT. 
      These findings would suggest the potential usefulness of baseline plasma BDNF 
      levels as predictors of response to ECT in treatment-resistant depressed 
      patients.
FAU - Piccinni, Armando
AU  - Piccinni A
AD  - Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, 
      University of Pisa, Via Roma 67, Pisa, Italy.
FAU - Del Debbio, Alessandro
AU  - Del Debbio A
FAU - Medda, Pierpaolo
AU  - Medda P
FAU - Bianchi, Carolina
AU  - Bianchi C
FAU - Roncaglia, Isabella
AU  - Roncaglia I
FAU - Veltri, Antonello
AU  - Veltri A
FAU - Zanello, Sara
AU  - Zanello S
FAU - Massimetti, Enrico
AU  - Massimetti E
FAU - Origlia, Nicola
AU  - Origlia N
FAU - Domenici, Luciano
AU  - Domenici L
FAU - Marazziti, Donatella
AU  - Marazziti D
FAU - Dell'Osso, Liliana
AU  - Dell'Osso L
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090215
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of 
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder, Major/*blood/*therapy
MH  - Electroconvulsive Therapy
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Statistics, Nonparametric
MH  - Treatment Outcome
EDAT- 2009/02/19 09:00
MHDA- 2009/06/06 09:00
CRDT- 2009/02/19 09:00
PHST- 2008/10/07 00:00 [received]
PHST- 2008/12/23 00:00 [revised]
PHST- 2009/01/08 00:00 [accepted]
PHST- 2009/02/19 09:00 [entrez]
PHST- 2009/02/19 09:00 [pubmed]
PHST- 2009/06/06 09:00 [medline]
AID - S0924-977X(09)00009-1 [pii]
AID - 10.1016/j.euroneuro.2009.01.002 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2009 May;19(5):349-55. doi: 
      10.1016/j.euroneuro.2009.01.002. Epub 2009 Feb 15.