PMID- 19223481
OWN - NLM
STAT- MEDLINE
DCOM- 20090508
LR  - 20211020
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Print)
IS  - 0019-9567 (Linking)
VI  - 77
IP  - 5
DP  - 2009 May
TI  - Interleukin-18-related genes are induced during the contraction phase but do not 
      play major roles in regulating the dynamics or function of the T-cell response to 
      Listeria monocytogenes infection.
PG  - 1894-903
LID - 10.1128/IAI.01315-08 [doi]
AB  - Proinflammatory cytokines, such as gamma interferon (IFN-gamma), impact aspects 
      of T-cell responses after infection, including expansion, contraction, and memory 
      formation. Interleukin-18 (IL-18) functions as a proinflammatory cytokine by 
      stimulating the production of IFN-gamma from multiple cell types and accentuating 
      the development of Th1 CD4 T-cell responses. Focused microarray analyses revealed 
      upregulation of IL-18 and IL-18 receptor genes in CD8 T cells during the 
      contraction phase. Based on these findings we investigated if and how signaling 
      through the IL-18 receptor influences the development and kinetics of antigen 
      (Ag)-specific CD8 and CD4 T-cell responses following infection. IL-18Ralpha(-/-) 
      and IL-18(-/-) mice developed frequencies and total numbers of Ag-specific CD8 T 
      cells after Listeria monocytogenes infection that were similar to those of 
      wild-type C57BL/6 mice. The kinetics of expansion, contraction, and memory CD8 
      T-cell maintenance were also similar. When IL-18Ralpha deficiency was isolated to 
      Ag-specific CD8 T cells, the kinetics of the expansion and contraction phases 
      were also normal. These basic findings were confirmed by examining the response 
      to vaccinia virus infection. In contrast, the expansion of Ag-specific CD4 T 
      cells was slightly curtailed by the absence of IL-18Ralpha; however, contraction 
      and the maintenance of memory were not altered. Importantly, both memory 
      Ag-specific CD8 and CD4 T cells generated in the absence of IL-18Ralpha expanded 
      appropriately after secondary antigen exposure and were protective, indicating 
      that signaling through the IL-18 receptor is not required for normal T-cell 
      response kinetics and survival of immunized mice challenged with a lethal L. 
      monocytogenes infection.
FAU - Haring, Jodie S
AU  - Haring JS
AD  - Department of Microbiology, 3-512 BSB, University of Iowa, 51 Newton Road, Iowa 
      City, IA 52242, USA.
FAU - Harty, John T
AU  - Harty JT
LA  - eng
GR  - R01 AI050073/AI/NIAID NIH HHS/United States
GR  - R01 AI042767/AI/NIAID NIH HHS/United States
GR  - AI42767/AI/NIAID NIH HHS/United States
GR  - AI50073/AI/NIAID NIH HHS/United States
GR  - R01 AI046653/AI/NIAID NIH HHS/United States
GR  - R37 AI042767/AI/NIAID NIH HHS/United States
GR  - R21 AI042767/AI/NIAID NIH HHS/United States
GR  - AI46653/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090217
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Interleukin-18)
RN  - 0 (Receptors, Interleukin-18)
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Interleukin-18/*biosynthesis/deficiency/*immunology
MH  - Listeria monocytogenes/*immunology
MH  - Listeriosis/*immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Receptors, Interleukin-18/deficiency/*immunology
MH  - T-Lymphocyte Subsets/immunology
PMC - PMC2681781
EDAT- 2009/02/19 09:00
MHDA- 2009/05/09 09:00
PMCR- 2009/11/01
CRDT- 2009/02/19 09:00
PHST- 2009/02/19 09:00 [entrez]
PHST- 2009/02/19 09:00 [pubmed]
PHST- 2009/05/09 09:00 [medline]
PHST- 2009/11/01 00:00 [pmc-release]
AID - IAI.01315-08 [pii]
AID - 1315-08 [pii]
AID - 10.1128/IAI.01315-08 [doi]
PST - ppublish
SO  - Infect Immun. 2009 May;77(5):1894-903. doi: 10.1128/IAI.01315-08. Epub 2009 Feb 
      17.