PMID- 19224602
OWN - NLM
STAT- MEDLINE
DCOM- 20090630
LR  - 20161125
IS  - 1098-2396 (Electronic)
IS  - 0887-4476 (Linking)
VI  - 63
IP  - 6
DP  - 2009 Jun
TI  - Nicotine sensitization and analysis of brain-derived neurotrophic factor in 
      adolescent beta-arrestin-2 knockout mice.
PG  - 510-9
LID - 10.1002/syn.20625 [doi]
AB  - Nicotine sensitization and levels of brain-derived neurotrophic factor (BDNF) 
      were analyzed in adolescent beta-arrestin-2 knockout (betaA-2 KO) and wild type 
      (WT) mice. The beta-arrestin-2 protein has been shown to be important in 
      G-protein hydrolysis and receptor internalization. Four- to five-week-old 
      adolescent betaA-2 KO and WT C57/Bl6 mice were administered either nicotine (0.5 
      mg/kg free base) or saline 10 min before being placed into a locomotor arena on 
      each of 7 (Experiment 1) or 14 (Experiment 2) consecutive days. A nicotine 
      challenge was given 7 days after sensitization was complete. In Experiment 1, 
      betaA-2 KO mice administered nicotine or saline and WT mice administered nicotine 
      demonstrated significant hypoactivity during early in testing, and neither WT nor 
      betaA-2 KO mice administered nicotine demonstrated sensitization. On the nicotine 
      challenge, WT mice administered nicotine demonstrated significantly higher 
      activity levels compared to all groups, and this same group demonstrated 
      significantly higher levels of accumbal BDNF compared to all groups. In 
      Experiment 2, betaA-2 KO mice were again hypoactive compared to WT mice, whereas 
      WT mice administered nicotine demonstrated significant hypoactivity during 
      initial testing and significantly higher levels of activity compared to all other 
      groups late in testing. On the nicotine challenge, WT mice that received nicotine 
      demonstrated a significant increase in activity compared to all groups, and 
      showed increased accumbal BDNF compared to all groups. These results show that 
      the beta-arrestin-2 protein is important in induction and expression of nicotine 
      sensitization as well as nicotine's effects on accumbal BDNF.
CI  - Copright 2009 Wiley-Liss, Inc.
FAU - Correll, Jennifer A
AU  - Correll JA
AD  - Department of Psychology, East Tennessee State University, Johnson City, 
      Tennessee 37614, USA.
FAU - Noel, Daniel M
AU  - Noel DM
FAU - Sheppard, A Brianna
AU  - Sheppard AB
FAU - Thompson, Kimberly N
AU  - Thompson KN
FAU - Li, Yi
AU  - Li Y
FAU - Yin, Deling
AU  - Yin D
FAU - Brown, Russell W
AU  - Brown RW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 0 (Arrb2 protein, mouse)
RN  - 0 (Arrestins)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nicotinic Agonists)
RN  - 0 (beta-Arrestin 2)
RN  - 0 (beta-Arrestins)
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Aging/genetics/*metabolism
MH  - Animals
MH  - Arrestins/*genetics
MH  - Brain Chemistry/genetics
MH  - Brain-Derived Neurotrophic Factor/analysis/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Motor Activity/drug effects/genetics
MH  - Nicotine/*pharmacology
MH  - Nicotinic Agonists/pharmacology
MH  - Nucleus Accumbens/drug effects/growth & development/metabolism
MH  - Up-Regulation/drug effects/genetics
MH  - beta-Arrestin 2
MH  - beta-Arrestins
EDAT- 2009/02/19 09:00
MHDA- 2009/07/01 09:00
CRDT- 2009/02/19 09:00
PHST- 2009/02/19 09:00 [entrez]
PHST- 2009/02/19 09:00 [pubmed]
PHST- 2009/07/01 09:00 [medline]
AID - 10.1002/syn.20625 [doi]
PST - ppublish
SO  - Synapse. 2009 Jun;63(6):510-9. doi: 10.1002/syn.20625.