PMID- 19225597
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1662-453X (Electronic)
IS  - 1662-4548 (Print)
IS  - 1662-453X (Linking)
VI  - 2
IP  - 2
DP  - 2008 Dec
TI  - Age-related decline in brain resources modulates genetic effects on cognitive 
      functioning.
PG  - 234-44
LID - 10.3389/neuro.01.039.2008 [doi]
AB  - Individual differences in cognitive performance increase from early to late 
      adulthood, likely reflecting influences of a multitude of factors. We hypothesize 
      that losses in neurochemical and anatomical brain resources in normal aging 
      modulate the effects of common genetic variations on cognitive functioning. Our 
      hypothesis is based on the assumption that the function relating brain resources 
      to cognition is nonlinear, so that genetic differences exert increasingly large 
      effects on cognition as resources recede from high to medium levels in the course 
      of aging. Direct empirical support for this hypothesis comes from a study by 
      Nagel et al. (2008), who reported that the effects of the 
      Catechol-O-Methyltransferase (COMT) gene on cognitive performance are magnified 
      in old age and interacted with the Brain-Derived Neurotrophic Factor (BDNF) gene. 
      We conclude that common genetic polymorphisms contribute to the increasing 
      heterogeneity of cognitive functioning in old age. Extensions of the hypothesis 
      to other polymorphisms are discussed. (150 of 150 words).
FAU - Lindenberger, Ulman
AU  - Lindenberger U
AD  - Max Planck Institute for Human Development Berlin, Germany.
FAU - Nagel, Irene E
AU  - Nagel IE
FAU - Chicherio, Christian
AU  - Chicherio C
FAU - Li, Shu-Chen
AU  - Li SC
FAU - Heekeren, Hauke R
AU  - Heekeren HR
FAU - Backman, Lars
AU  - Backman L
LA  - eng
PT  - Journal Article
DEP - 20081215
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC2622748
OTO - NOTNLM
OT  - aging
OT  - cognition
OT  - dopamine
OT  - genes
OT  - resources
EDAT- 2009/02/20 09:00
MHDA- 2009/02/20 09:01
PMCR- 2008/12/01
CRDT- 2009/02/20 09:00
PHST- 2008/10/05 00:00 [received]
PHST- 2008/11/11 00:00 [accepted]
PHST- 2009/02/20 09:00 [entrez]
PHST- 2009/02/20 09:00 [pubmed]
PHST- 2009/02/20 09:01 [medline]
PHST- 2008/12/01 00:00 [pmc-release]
AID - 10.3389/neuro.01.039.2008 [doi]
PST - epublish
SO  - Front Neurosci. 2008 Dec 15;2(2):234-44. doi: 10.3389/neuro.01.039.2008. 
      eCollection 2008 Dec.