PMID- 19227199
OWN - NLM
STAT- MEDLINE
DCOM- 20090409
LR  - 20190917
IS  - 0030-154X (Print)
IS  - 0030-154X (Linking)
VI  - 85
IP  - 3
DP  - 2008 Nov
TI  - The presence of intra-tubular lymphocytes in normal testis of the mouse.
PG  - 91-6
AB  - Spermatoza contain various autoimmunogenic materials, which are recognized as 
      foreign by the self immune system. Therefore, the blood-tesits-barrier (BTB) 
      formed by Sertoli cells, basal lamina and myoid cells protects autoimmunogeneic 
      spermatozoa from attack by the self immune system. However, the BTB at the tubuli 
      recti (TR) and the rete testis (RT) is known to be incomplete against humoral 
      substances. We investigated here whether the BTB is physiologically penetrated by 
      lymphocytes in mice. We performed light and electron microscopical observation of 
      the seminiferous tubules (ST), the TR and the RT in normal C3H/IHe mice. Although 
      no lymphocytes were observed inside the ST, a very few lymphocytes could be found 
      beyond the basal lamina of the TR and the RT. These lymphocytes were close to 
      testicular spermatozoa in the TR lumen. These findings provide a possibility that 
      lymphocytes may gain access to autoantigens of spermatozoa inside the TR and RT 
      under physiological conditions in mice.
FAU - Naito, Munekazu
AU  - Naito M
AD  - Department of Anatomy, Tokyo Medical University, Tokyo, Japan. 
      munekazu@tokyo-med.ac.jp
FAU - Terayama, Hayato
AU  - Terayama H
FAU - Hirai, Shuichi
AU  - Hirai S
FAU - Qu, Ning
AU  - Qu N
FAU - Moriyama, Hiroshi
AU  - Moriyama H
FAU - Itoh, Masahiro
AU  - Itoh M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Okajimas Folia Anat Jpn
JT  - Okajimas folia anatomica Japonica
JID - 0401014
RN  - 0 (Autoantigens)
SB  - IM
MH  - Animals
MH  - Autoantigens/immunology
MH  - Autoimmunity/*physiology
MH  - Basement Membrane/immunology/ultrastructure
MH  - Blood-Testis Barrier/immunology/*ultrastructure
MH  - Lymphocytes/immunology/*ultrastructure
MH  - Male
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Microscopy, Electron, Transmission
MH  - Rete Testis/immunology/*ultrastructure
MH  - Seminiferous Tubules/immunology/*ultrastructure
MH  - Sertoli Cells/immunology/ultrastructure
MH  - Spermatogenesis/immunology
MH  - Spermatozoa/immunology/ultrastructure
MH  - Testis/immunology/*ultrastructure
EDAT- 2009/02/21 09:00
MHDA- 2009/04/10 09:00
CRDT- 2009/02/21 09:00
PHST- 2009/02/21 09:00 [entrez]
PHST- 2009/02/21 09:00 [pubmed]
PHST- 2009/04/10 09:00 [medline]
AID - 10.2535/ofaj.85.91 [doi]
PST - ppublish
SO  - Okajimas Folia Anat Jpn. 2008 Nov;85(3):91-6. doi: 10.2535/ofaj.85.91.