PMID- 19227412
OWN - NLM
STAT- MEDLINE
DCOM- 20090331
LR  - 20220311
IS  - 0041-4301 (Print)
IS  - 0041-4301 (Linking)
VI  - 50
IP  - 6
DP  - 2008 Nov-Dec
TI  - HLA types in Turkish children with celiac disease.
PG  - 515-20
AB  - The aim of this study was to assess the distribution of human leukocyte antigen 
      (HLA) groups in Turkish children with celiac disease (CD) and to investigate the 
      association of HLA types and clinical manifestations of CD. Seventy-five children 
      with CD were evaluated in two groups: Group I consisted of 45 classical celiac 
      patients (15 males, 6.7+/-3.8 years); Group II consisted of 30 atypical celiac 
      patients (9 males, 9.3+/-4.3 years). The control group consisted of 100 healthy 
      renal transplantation donors. HLA typing was made serologically using standard 
      lymphocytotoxicity techniques. HLA A29, B51, CW5, DR14, DR16, and DQ1 were the 
      most common antigens in the control group. Frequency of HLA B13, CW7, B8, DR7, 
      DR17 and DQ2 was higher in CD patients than in the control group (p<0.005, <0.05, 
      <0.001, <0.001 and <0.001, respectively). The relative risks for HLA DQ2, B8, 
      DR17 and B13 were 14.9, 13.6, 7.1 and 3.6, respectively. Frequency of HLA B35, 
      DR11 and DQ7 was higher in classical CD than atypical CD, while a positive 
      association was found between HLA B8 and atypical CD. A positive association was 
      found between HLA B13, CW7 and DR17 in Turkish celiac patients in addition to HLA 
      B8, DR7 and DQ2. This study also suggested that a correlation may exist between 
      genotype and clinical manifestations.
FAU - Kuloglu, Zarife
AU  - Kuloglu Z
AD  - Department of Pediatric Gastroenterology, Ankara University Faculty of Medicine, 
      Ankara, Turkey.
FAU - Doganci, Tumay
AU  - Doganci T
FAU - Kansu, Aydan
AU  - Kansu A
FAU - Demirceken, Fulya
AU  - Demirceken F
FAU - Duman, Murat
AU  - Duman M
FAU - Tutkak, Huseyin
AU  - Tutkak H
FAU - Ensari, Arzu
AU  - Ensari A
FAU - Girgin, Nurten
AU  - Girgin N
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Turk J Pediatr
JT  - The Turkish journal of pediatrics
JID - 0417505
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Celiac Disease/genetics/*immunology
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Genotype
MH  - HLA Antigens/genetics/*immunology
MH  - Humans
MH  - Infant
MH  - Male
MH  - Turkey
EDAT- 2009/02/21 09:00
MHDA- 2009/04/01 09:00
CRDT- 2009/02/21 09:00
PHST- 2009/02/21 09:00 [entrez]
PHST- 2009/02/21 09:00 [pubmed]
PHST- 2009/04/01 09:00 [medline]
PST - ppublish
SO  - Turk J Pediatr. 2008 Nov-Dec;50(6):515-20.