PMID- 1922933
OWN - NLM
STAT- MEDLINE
DCOM- 19911031
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 126
IP  - 2
DP  - 1991 May 27
TI  - 2-Chloroadenosine attenuates NMDA, kainate, and quisqualate toxicity.
PG  - 191-4
AB  - Excitatory amino acid (EAA)-induced cell death in the striatum is dependent upon 
      intact glutamatergic afferents arising from the cerebral cortex. Through a 
      mechanism possibly related to inhibition of glutamate release, adenosine receptor 
      agonists attenuate EAA induced toxicity in the rat striatum. In the present 
      study, we examined whether 2-chloroadenosine (2CLA), a stable adenosine analog, 
      protects against toxicity induced by kainate (KA), quisqualate (QUIS), 
      N-methyl-D-aspartate (NMDA), and ibotenate (IBO). In vivo intrastriatal 
      injections of 2CLA (50 nmol) with each EAA tested provided a partial but 
      significant protective effect versus injection of the EAA alone, as measured by 
      striatal concentrations of gamma-aminobutyric acid (GABA) and substance P-like 
      immunoreactivity (SP-LI). These results show that 2CLA attenuates both NMDA- and 
      non-NMDA-mediated neuronal cell death.
FAU - Finn, S F
AU  - Finn SF
AD  - Neurochemistry Laboratory, Massachusetts General Hospital, Boston 02114.
FAU - Swartz, K J
AU  - Swartz KJ
FAU - Beal, M F
AU  - Beal MF
LA  - eng
GR  - NINDS 16367/DS/DS NIH HHS/United States
GR  - NS 10828-14A/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 146-77-0 (2-Chloroadenosine)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 8OC22C1B99 (Quisqualic Acid)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - 2-Chloroadenosine/*pharmacology
MH  - Animals
MH  - Corpus Striatum/*drug effects/pathology
MH  - Injections
MH  - Kainic Acid/antagonists & inhibitors/*toxicity
MH  - Male
MH  - N-Methylaspartate/antagonists & inhibitors/*toxicity
MH  - Quisqualic Acid/antagonists & inhibitors/*toxicity
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1991/05/27 00:00
MHDA- 1991/05/27 00:01
CRDT- 1991/05/27 00:00
PHST- 1991/05/27 00:00 [pubmed]
PHST- 1991/05/27 00:01 [medline]
PHST- 1991/05/27 00:00 [entrez]
AID - 0304-3940(91)90551-4 [pii]
AID - 10.1016/0304-3940(91)90551-4 [doi]
PST - ppublish
SO  - Neurosci Lett. 1991 May 27;126(2):191-4. doi: 10.1016/0304-3940(91)90551-4.