PMID- 19231103
OWN - NLM
STAT- MEDLINE
DCOM- 20090910
LR  - 20181201
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 75
IP  - 1
DP  - 2009 Sep 1
TI  - Does three-dimensional external beam partial breast irradiation spare lung tissue 
      compared with standard whole breast irradiation?
PG  - 82-8
LID - 10.1016/j.ijrobp.2008.10.041 [doi]
AB  - PURPOSE: To determine whether three-dimensional conformal partial breast 
      irradiation (3D-PBI) spares lung tissue compared with whole breast irradiation 
      (WBI) and to include the biologically equivalent dose (BED) to account for 
      differences in fractionation. METHODS AND MATERIALS: Radiotherapy treatment plans 
      were devised for WBI and 3D-PBI for 25 consecutive patients randomized on the 
      NSABP B-39/RTOG 0413 protocol at Mayo Clinic in Jacksonville, Florida. WBI plans 
      were for 50 Gy in 25 fractions, and 3D-PBI plans were for 38.5 Gy in 10 
      fractions. Volume of ipsilateral lung receiving 2.5, 5, 10, and 20 Gy was 
      recorded for each plan. The linear quadratic equation was used to calculate the 
      corresponding dose delivered in 10 fractions and volume of ipsilateral lung 
      receiving these doses was recorded for PBI plans. Ipsilateral mean lung dose was 
      recorded for each plan and converted to BED. RESULTS: There was a significant 
      decrease in volume of lung receiving 20 Gy with PBI (median, 4.4% vs. 7.5%; p < 
      0.001), which remained after correction for fractionation (median, 5.6% vs. 7.5%; 
      p = 0.02). Mean lung dose was lower for PBI (median, 3.46 Gy vs. 4.57 Gy; p = 
      0.005), although this difference lost significance after conversion to BED 
      (median, 3.86 Gy(3) vs 4.85 Gy(3), p = 0.07). PBI plans exposed more lung to 2.5 
      and 5 Gy. CONCLUSIONS: 3D-PBI exposes greater volumes of lung tissue to low doses 
      of radiation and spares the amount of lung receiving higher doses when compared 
      with WBI.
FAU - Jain, Anudh K
AU  - Jain AK
AD  - Department of Radiation Oncology, Mayo Clinic, Jacksonville, Florida, USA.
FAU - Vallow, Laura A
AU  - Vallow LA
FAU - Gale, Ashley A
AU  - Gale AA
FAU - Buskirk, Steven J
AU  - Buskirk SJ
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20090221
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
CIN - Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3):956-7; author reply 957. PMID: 
      20159367
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Algorithms
MH  - Breast Neoplasms/diagnostic imaging/pathology/*radiotherapy
MH  - Dose Fractionation, Radiation
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Lung/*radiation effects
MH  - Middle Aged
MH  - Radiation Injuries/*prevention & control
MH  - Radiography
MH  - Radiotherapy, Conformal/*methods
MH  - Relative Biological Effectiveness
EDAT- 2009/02/24 09:00
MHDA- 2009/09/11 06:00
CRDT- 2009/02/24 09:00
PHST- 2008/08/06 00:00 [received]
PHST- 2008/10/08 00:00 [revised]
PHST- 2008/10/22 00:00 [accepted]
PHST- 2009/02/24 09:00 [entrez]
PHST- 2009/02/24 09:00 [pubmed]
PHST- 2009/09/11 06:00 [medline]
AID - S0360-3016(08)03680-8 [pii]
AID - 10.1016/j.ijrobp.2008.10.041 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2009 Sep 1;75(1):82-8. doi: 
      10.1016/j.ijrobp.2008.10.041. Epub 2009 Feb 21.