PMID- 19231591
OWN - NLM
STAT- MEDLINE
DCOM- 20090406
LR  - 20221207
IS  - 0065-2776 (Print)
IS  - 1557-8445 (Electronic)
IS  - 0065-2776 (Linking)
VI  - 101
DP  - 2009
TI  - TSLP in epithelial cell and dendritic cell cross talk.
PG  - 1-25
LID - 10.1016/S0065-2776(08)01001-8 [doi]
AB  - Dendritic cells (DCs) are professional antigen-presenting cells that have the 
      ability to sense infection and tissue stress, sample and present antigen to T 
      lymphocytes, and instruct the initiation of different forms of immunity and 
      tolerance. The functional versatility of DCs depends on their remarkable ability 
      to translate collectively the information from the invading microbes, as well as 
      their resident tissue microenvironments. Recent progress in understanding 
      Toll-like receptor (TLR) biology has illuminated the mechanisms by which DCs link 
      innate and adaptive antimicrobial immune responses. However, how tissue 
      microenvironments shape the function of DCs has remained elusive. Recent studies 
      of TSLP (thymic stromal lymphopoietin), an epithelial cell-derived cytokine that 
      strongly activates DCs, provide strong evidence at a molecular level that 
      epithelial cells/tissue microenvironments directly communicate with DCs, the 
      professional antigen-presenting cells of the immune system. We review recent 
      progress on how TSLP expressed within thymus and peripheral lymphoid and 
      nonlymphoid tissues regulates DC-mediated central tolerance, peripheral T cell 
      homeostasis, and inflammatory Th2 responses.
FAU - Liu, Yong-Jun
AU  - Liu YJ
AD  - Department of Immunology, Center for Cancer Immunology Research, The University 
      of Texas, M. D. Anderson Cancer Center, Houston, Texas, USA.
LA  - eng
GR  - R01 AI061645/AI/NIAID NIH HHS/United States
GR  - U19 AI071130/AI/NIAID NIH HHS/United States
GR  - AI061645/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Adv Immunol
JT  - Advances in immunology
JID - 0370425
RN  - 0 (CRLF2 protein, human)
RN  - 0 (Cytokines)
RN  - 0 (Receptors, Cytokine)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
SB  - IM
MH  - Animals
MH  - Cell Communication/immunology
MH  - Cytokines/*immunology/metabolism
MH  - Dendritic Cells/*immunology/metabolism
MH  - Epithelial Cells/cytology/*immunology/metabolism
MH  - Humans
MH  - Hypersensitivity/*immunology/metabolism
MH  - Inflammation/*immunology/metabolism
MH  - Mast Cells/immunology/metabolism
MH  - Natural Killer T-Cells/immunology/metabolism
MH  - Receptors, Cytokine/*immunology/metabolism
MH  - T-Lymphocyte Subsets/immunology/metabolism
MH  - Thymus Gland/cytology/immunology/metabolism
MH  - Thymic Stromal Lymphopoietin
PMC - PMC3645262
MID - NIHMS465476
EDAT- 2009/02/24 09:00
MHDA- 2009/04/07 09:00
PMCR- 2013/05/06
CRDT- 2009/02/24 09:00
PHST- 2009/02/24 09:00 [entrez]
PHST- 2009/02/24 09:00 [pubmed]
PHST- 2009/04/07 09:00 [medline]
PHST- 2013/05/06 00:00 [pmc-release]
AID - S0065-2776(08)01001-8 [pii]
AID - 10.1016/S0065-2776(08)01001-8 [doi]
PST - ppublish
SO  - Adv Immunol. 2009;101:1-25. doi: 10.1016/S0065-2776(08)01001-8.