PMID- 19232278
OWN - NLM
STAT- MEDLINE
DCOM- 20100823
LR  - 20090223
IS  - 1558-1950 (Electronic)
IS  - 1052-5157 (Linking)
VI  - 19
IP  - 1
DP  - 2009 Jan
TI  - Functional heartburn: what it is and how to treat it.
PG  - 23-33, v
LID - 10.1016/j.giec.2008.12.002 [doi]
AB  - Functional heartburn is considered one of the most common functional esophageal 
      disorders. The disorder is more common in young women and is associated with 
      other functional bowel disorders and psychological co-morbidity, primarily 
      somatization. The etiology of functional heartburn remains unknown. Most 
      patients, however, demonstrate esophageal hypersensitivity. Functional heartburn 
      has been identified as the main cause for proton pump inhibitor (PPI) failure in 
      patients with heartburn. Treatment is still a challenge, and patients should be 
      started with PPI treatment. In non-responders, escalation of the PPI dose could 
      be attempted and, if unsuccessful, pain modulators should be prescribed.
FAU - Fass, Ronnie
AU  - Fass R
AD  - Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health 
      Care System and University of Arizona Health Sciences Center, GI Section 
      (1-111G-1), 3601 South. 6th Avenue, Tucson, AZ 85723-0001, USA. 
      Ronnie.Fass@va.gov
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Gastrointest Endosc Clin N Am
JT  - Gastrointestinal endoscopy clinics of North America
JID - 9202792
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Anti-Ulcer Agents/*therapeutic use
MH  - Esophageal pH Monitoring/instrumentation
MH  - Esophagoscopy
MH  - Esophagus/physiopathology
MH  - Female
MH  - *Heartburn/diagnosis/drug therapy/etiology/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*therapeutic use
RF  - 46
EDAT- 2009/02/24 09:00
MHDA- 2010/08/24 06:00
CRDT- 2009/02/24 09:00
PHST- 2009/02/24 09:00 [entrez]
PHST- 2009/02/24 09:00 [pubmed]
PHST- 2010/08/24 06:00 [medline]
AID - S1052-5157(08)00106-2 [pii]
AID - 10.1016/j.giec.2008.12.002 [doi]
PST - ppublish
SO  - Gastrointest Endosc Clin N Am. 2009 Jan;19(1):23-33, v. doi: 
      10.1016/j.giec.2008.12.002.