PMID- 192329
OWN - NLM
STAT- MEDLINE
DCOM- 19770611
LR  - 20131121
IS  - 0320-9725 (Print)
IS  - 0320-9725 (Linking)
VI  - 41
IP  - 10
DP  - 1976 Oct
TI  - [Some characteristics of isoenzymic spectrum of hexokinase and glucose levels in 
      hepatomas and liver of the host].
PG  - 1766-72
AB  - The total activity of hexokinase (HK) and HK isoenzymic spectrum of the normal 
      liver and slowly groming hepatoma 49 did not show any essential differences. 
      However, the HK total activity and the relative and absolute contents of 
      isoenzyme HK-3 were increased in hepatomas 61 and especially in the rapidly 
      growing hepatoma 22-a. The glucokinase activity decreases in the hepatiomas 49 
      and 61 and disappears in the rapidly growing hepatoma 22-a. The glucose content 
      in hepatoma 49 was slightly lower than in the normal liver, whereas in other 
      hepatoma no traces of glucose could be detected. At low glucose concentration in 
      the medium (0,1 mM), i.e. under conditions simulating those characteristic of 
      tumors in vivo, the predominant form of HK in all hepatomas studied was found to 
      be HK-3. In the liver of hepatoma-bearing mice some shifts in the value of total 
      HK activity and its isoenzymic spectrum, reminding one of those found in 
      hepatomas themselves, were observed. Unequal deviations in the total HK activity 
      and its isoenzymic spectrum in hepatomas with different degrees of malignancy 
      indicate that these characteristics are secondary rather than primary events 
      depending on tumour progression.
FAU - Shapot, V S
AU  - Shapot VS
FAU - Gorozhanskaia, E G
AU  - Gorozhanskaia EG
FAU - Liubimova, N A
AU  - Liubimova NA
LA  - rus
PT  - English Abstract
PT  - Journal Article
TT  - Osobennosti izofermentnogo spektra geksokinazy i urovnia gliukozy v gepatomakh i 
      pecheni opukholevogo organizma.
PL  - Russia (Federation)
TA  - Biokhimiia
JT  - Biokhimiia (Moscow, Russia)
JID - 0372667
RN  - 0 (Isoenzymes)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Carcinoma, Hepatocellular/*metabolism
MH  - Glucose/*metabolism
MH  - Hexokinase/*metabolism
MH  - Isoenzymes/*metabolism
MH  - Liver/*metabolism
MH  - Liver Neoplasms/*metabolism
MH  - Mice
MH  - Neoplasms, Experimental/metabolism
EDAT- 1976/10/01 00:00
MHDA- 1976/10/01 00:01
CRDT- 1976/10/01 00:00
PHST- 1976/10/01 00:00 [pubmed]
PHST- 1976/10/01 00:01 [medline]
PHST- 1976/10/01 00:00 [entrez]
PST - ppublish
SO  - Biokhimiia. 1976 Oct;41(10):1766-72.