PMID- 19234214
OWN - NLM
STAT- MEDLINE
DCOM- 20090421
LR  - 20090223
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Linking)
VI  - 182
IP  - 5
DP  - 2009 Mar 1
TI  - Differential migration of epidermal and dermal dendritic cells during skin 
      infection.
PG  - 3165-72
LID - 10.4049/jimmunol.0802950 [doi]
AB  - Dendritic cells (DCs) are extremely heterogeneous, most evident in the skin where 
      a variety of different subsets have been identified in recent years. DCs of 
      healthy skin include a number of distinct populations in the dermal layer as well 
      as the well-characterized Langerhans cells (LCs) of the epidermis. These 
      steady-state populations are augmented during bouts of local inflammation by 
      additional monocyte-derived DCs. In an effort to better understand the 
      distinction between the different subsets, we examined their behavior following 
      skin infection with HSV. LC emigration rapidly followed appearance of virus in 
      the skin and resulted in depopulation of regions in areas surrounding infected 
      nerve endings. A separate DC population was found to accumulate within the dermis 
      under patches of active epidermal infection with at least some derived from blood 
      monocyte precursors. Ag-positive DCs could occasionally be found in these dermal 
      accumulations, although they represented a minority of DCs in these areas. In 
      addition, infected DCs appeared compromised in their trafficking capabilities and 
      were largely absent from the migrating population. On resolution of skin disease, 
      LCs repopulated the reformed epidermis and these were of mixed origin, with 
      around half entering from the circulation and the remainder derived from local 
      progenitors. Overall, our results show a range of migrational complexities 
      between distinct skin DC populations as a consequence of localized infection.
FAU - Eidsmo, Liv
AU  - Eidsmo L
AD  - Department of Microbiology and Immunology, University of Melbourne, Melbourne 
      Victoria, Australia.
FAU - Allan, Rhys
AU  - Allan R
FAU - Caminschi, Irina
AU  - Caminschi I
FAU - van Rooijen, Nico
AU  - van Rooijen N
FAU - Heath, William R
AU  - Heath WR
FAU - Carbone, Francis R
AU  - Carbone FR
LA  - eng
GR  - Howard Hughes Medical Institute/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
SB  - IM
MH  - Animals
MH  - Cell Aggregation/immunology
MH  - Dendritic Cells/*immunology/pathology/virology
MH  - Dermis/*immunology/pathology/virology
MH  - Epidermis/*immunology/pathology/virology
MH  - Herpes Simplex/*immunology/*pathology
MH  - Herpesvirus 1, Human/*immunology
MH  - Langerhans Cells/immunology/pathology/virology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Monocytes/immunology/pathology/virology
MH  - Stem Cells/immunology/pathology/virology
EDAT- 2009/02/24 09:00
MHDA- 2009/04/22 09:00
CRDT- 2009/02/24 09:00
PHST- 2009/02/24 09:00 [entrez]
PHST- 2009/02/24 09:00 [pubmed]
PHST- 2009/04/22 09:00 [medline]
AID - 182/5/3165 [pii]
AID - 10.4049/jimmunol.0802950 [doi]
PST - ppublish
SO  - J Immunol. 2009 Mar 1;182(5):3165-72. doi: 10.4049/jimmunol.0802950.