PMID- 19234630
OWN - NLM
STAT- MEDLINE
DCOM- 20090317
LR  - 20211020
IS  - 1090-0535 (Electronic)
IS  - 1090-0535 (Linking)
VI  - 15
DP  - 2009
TI  - PDCD1 genes may protect against extraocular manifestations in Chinese Han 
      patients with Vogt-Koyanagi-Harada syndrome.
PG  - 386-92
AB  - PURPOSE: To analyze the potential association of programmed cell death 1 (PDCD1) 
      with Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population. METHODS: 
      Three single nucleotide polymorphism (SNPs), PD-1.3G/A, PD-1.5C/T, and PD-1.6G/A, 
      were genotyped in 247 VKH patients and 289 age-, sex-, and ethnically-matched 
      healthy controls using polymerase chain reaction-restriction fragment length 
      polymorphism (PCR-RFLP) assay. The associations of genotypes and alleles with VKH 
      syndrome were analyzed. RESULTS: All genotype distributions in healthy controls 
      were in Hardy-Weinberg equilibrium. The genotype and allele frequencies of 
      PD-1.3, PD-1.5, and PD-1.6 were not different between patients with VKH syndrome 
      and healthy controls. No significant difference was observed according to the 
      status of human leukocyte antigen (HLA)-DR4 and HLA-DRw53. Compared to the 
      controls, lower frequencies of the PD-1.5C genotype and allele frequencies were 
      observed in VKH patients with extraocular findings. CONCLUSIONS: PD-1.3 and 
      PD-1.6 polymorphisms are not associated with the susceptibility to VKH syndrome 
      in the Chinese Han population. However, PD-1.5 may be negatively associated with 
      the occurrence of extraocular manifestations of VKH syndrome.
FAU - Meng, Qianli
AU  - Meng Q
AD  - Zhongshan Ophthalmic Center, Sun Yat-sen University, Uveitis Study Center of Sun 
      Yat-sen University and International Uveitis Study Laboratory of Guangdong 
      Province, State Key Laboratory of Ophthalmology of Sun Yat-sen University, 
      Guangzhou, P.R.China.
FAU - Liu, Xiaoli
AU  - Liu X
FAU - Yang, Peizeng
AU  - Yang P
FAU - Hou, Shengping
AU  - Hou S
FAU - Du, Liping
AU  - Du L
FAU - Zhou, Hongyan
AU  - Zhou H
FAU - Kijlstra, Aize
AU  - Kijlstra A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090220
PL  - United States
TA  - Mol Vis
JT  - Molecular vision
JID - 9605351
RN  - 0 (Antigens, CD)
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR4 Antigen)
RN  - 0 (HLA-DR53)
RN  - 0 (HLA-DRB4 Chains)
RN  - 0 (PDCD1 protein, human)
RN  - 0 (Programmed Cell Death 1 Receptor)
SB  - IM
MH  - Adult
MH  - Antigens, CD/*genetics
MH  - Apoptosis Regulatory Proteins/*genetics
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - China/epidemiology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DR Antigens/genetics
MH  - HLA-DR4 Antigen/genetics
MH  - HLA-DRB4 Chains
MH  - Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Polymorphism, Restriction Fragment Length
MH  - *Polymorphism, Single Nucleotide
MH  - Programmed Cell Death 1 Receptor
MH  - Uveomeningoencephalitic Syndrome/epidemiology/*genetics/*pathology
PMC - PMC2645903
EDAT- 2009/02/24 09:00
MHDA- 2009/03/18 09:00
PMCR- 2009/01/01
CRDT- 2009/02/24 09:00
PHST- 2008/12/20 00:00 [received]
PHST- 2009/02/13 00:00 [accepted]
PHST- 2009/02/24 09:00 [entrez]
PHST- 2009/02/24 09:00 [pubmed]
PHST- 2009/03/18 09:00 [medline]
PHST- 2009/01/01 00:00 [pmc-release]
AID - 40 [pii]
AID - 2008MOLVIS0415 [pii]
PST - ppublish
SO  - Mol Vis. 2009;15:386-92. Epub 2009 Feb 20.