PMID- 19235789
OWN - NLM
STAT- MEDLINE
DCOM- 20100825
LR  - 20090820
IS  - 1099-1166 (Electronic)
IS  - 0885-6230 (Linking)
VI  - 24
IP  - 9
DP  - 2009 Sep
TI  - Investigation of dopamine receptors in susceptibility to behavioural and 
      psychological symptoms in Alzheimer's disease.
PG  - 1020-5
LID - 10.1002/gps.2214 [doi]
AB  - OBJECTIVE: Alzheimer's disease (AD) patients commonly suffer from behavioural and 
      psychological symptoms of dementia (BPSD). A genetic component to the development 
      of BPSD in AD has been supported. Polymorphisms within dopamine receptors DRD1, 
      DRD2, DRD3 and DRD4 have previously been investigated in a few interesting 
      studies that are reviewed here and extended using our patient cohort. METHODS: 
      Our large cohort of 395 probable AD patients had longitudinal information on the 
      BPSD (Neuropsychiatric Inventory), which was used to dichotomise patients into 
      whether they had ever suffered from a given symptom within the study period, or 
      not. These measures were related to the DRD1 (A-48G), DRD2 (ser311cys; 
      C-ins/del), DRD3 (ser9gly) and DRD4 (VNTR) genotype and allele frequencies. 
      RESULTS: Associations were revealed between DRD3 and elation, and between DRD4 
      with agitation/aggression and with depression; however, these findings do not 
      remain significant after correction for multiple testing. No associations were 
      found with the other genetic variants and these symptoms and no associations were 
      observed between any of the polymorphic variants examined and delusions, 
      hallucinations, psychosis and aberrant motor behaviour. CONCLUSION: Our data, in 
      combination with a review of the literature, reveal a potential role for the VNTR 
      variant of DRD4 in the development of depression in AD patients. The findings 
      presented here need to be replicated in large, well characterised longitudinal 
      cohorts.
FAU - Pritchard, Antonia L
AU  - Pritchard AL
AD  - Molecular Psychiatry Group, Population Studies and Human Genetics, G Floor CBCRC 
      Building, Queensland Institute of Medical Research, Herston, Brisbane, 4006, 
      Australia. Antonia.Pritchard@qimr.edu.au
FAU - Ratcliffe, Laura
AU  - Ratcliffe L
FAU - Sorour, Eman
AU  - Sorour E
FAU - Haque, Sayeed
AU  - Haque S
FAU - Holder, Roger
AU  - Holder R
FAU - Bentham, Peter
AU  - Bentham P
FAU - Lendon, Corinne L
AU  - Lendon CL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int J Geriatr Psychiatry
JT  - International journal of geriatric psychiatry
JID - 8710629
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - 0 (Receptors, Dopamine)
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*genetics/psychology
MH  - Dopamine Plasma Membrane Transport Proteins/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Mental Disorders/genetics/psychology
MH  - Receptors, Dopamine/*genetics
MH  - Risk Factors
RF  - 23
EDAT- 2009/02/25 09:00
MHDA- 2010/08/26 06:00
CRDT- 2009/02/25 09:00
PHST- 2009/02/25 09:00 [entrez]
PHST- 2009/02/25 09:00 [pubmed]
PHST- 2010/08/26 06:00 [medline]
AID - 10.1002/gps.2214 [doi]
PST - ppublish
SO  - Int J Geriatr Psychiatry. 2009 Sep;24(9):1020-5. doi: 10.1002/gps.2214.