PMID- 19235869
OWN - NLM
STAT- MEDLINE
DCOM- 20090325
LR  - 20111117
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 81
IP  - 4
DP  - 2009 Apr
TI  - Human leukocyte antigen-DRB1*1101 correlates with less severe hepatitis in 
      Taiwanese male carriers of hepatitis B virus.
PG  - 588-93
LID - 10.1002/jmv.21448 [doi]
AB  - Human leukocyte antigen (HLA) class II molecules are associated with host immune 
      responses against hepatitis B virus infection. Male gender is the apparent host 
      factor when someone encounters with the severity of hepatitis. The aim of this 
      study was to investigate the association of the most polymorphic HLA class II 
      allele, human leukocyte antigen-DRB1, with the severity of hepatitis in male 
      carriers of hepatitis B virus. In this prospective cohort study, a total of 204 
      carriers of hepatitis B virus (131 men and 73 women) who have been followed-up 
      for more than 1 year at the outpatient clinic of a university hospital were 
      collected consecutively. Fifty carriers of hepatitis B virus (group I) with 
      alanine aminotransferase <2x upper limit of normal (mean follow-up 83.6 months) 
      were compared with 154 chronic hepatitis B patients (group II) with alanine 
      aminotransferase >/=2x upper limit of normal (mean follow-up 81.3 months). 
      Alleles of HLA-DRB1 were typed by the polymerase chain reaction-sequence specific 
      oligonucleotide probe hybridization and genotypes of hepatitis B virus by melting 
      curve analysis. HLA-DRB1*1101 was found in 18% of group I versus 8% of group II 
      in male carriers (OR 0.23, P = 0.020, after adjustment for age) and 4% versus 
      9.4% in female carriers (P = 0.094). In male carriers harboring DRB1*1101, the 
      distribution of hepatitis B viral genotype was comparable between the two groups. 
      HLA-DRB1*1101 correlates with less severe hepatitis in Taiwanese male carriers of 
      hepatitis B virus.
CI  - (c) 2009 Wiley-Liss, Inc.
FAU - Huang, Yi-Wen
AU  - Huang YW
AD  - Liver Unit, Cathay General Hospital Medical Center, Taipei, Taiwan.
FAU - Hu, Chung-Yi
AU  - Hu CY
FAU - Chen, Chi-Lin
AU  - Chen CL
FAU - Liao, Ya-Tang
AU  - Liao YT
FAU - Liu, Chun-Jen
AU  - Liu CJ
FAU - Lai, Ming-Yang
AU  - Lai MY
FAU - Chen, Pei-Jer
AU  - Chen PJ
FAU - Yang, Sien-Sing
AU  - Yang SS
FAU - Hu, Jui-Ting
AU  - Hu JT
FAU - Chen, Ding-Shinn
AU  - Chen DS
FAU - Kao, Jia-Horng
AU  - Kao JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Carrier State/*physiopathology/virology
MH  - Cohort Studies
MH  - Female
MH  - Genotype
MH  - HLA-DR Antigens/classification/*genetics/metabolism
MH  - HLA-DRB1 Chains
MH  - Hepatitis B virus/*pathogenicity
MH  - Hepatitis B, Chronic/*genetics/*physiopathology/virology
MH  - Hospitals, University
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - *Severity of Illness Index
MH  - Taiwan
EDAT- 2009/02/25 09:00
MHDA- 2009/03/26 09:00
CRDT- 2009/02/25 09:00
PHST- 2009/02/25 09:00 [entrez]
PHST- 2009/02/25 09:00 [pubmed]
PHST- 2009/03/26 09:00 [medline]
AID - 10.1002/jmv.21448 [doi]
PST - ppublish
SO  - J Med Virol. 2009 Apr;81(4):588-93. doi: 10.1002/jmv.21448.