PMID- 19236318
OWN - NLM
STAT- MEDLINE
DCOM- 20100106
LR  - 20090921
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 64
IP  - 9
DP  - 2009 Sep
TI  - Neuropsychologic status at the age 4 years and atopy in a population-based birth 
      cohort.
PG  - 1279-85
LID - 10.1111/j.1398-9995.2009.01987.x [doi]
AB  - BACKGROUND: Mental health has been reported to be associated with allergy, but 
      only a few cohort studies have assessed if neurodevelopment predicts atopy. 
      OBJECTIVE: To investigate if neurobehavioral status of healthy 4-year-old 
      children was associated with specific immunoglobulin E (IgE) at the same age and 
      skin prick test results 2 years later. METHODS: A population-based birth cohort 
      enrolled 482 children, 422 of them (87%) provided neurobehavioral data, 341 (71%) 
      had specific IgE measured at the age of 4 years; and 395 (82%) had skin prick 
      tests completed at the age of 6 years. Atopy was defined as IgE levels higher 
      than 0.35 kU/l to any of the three tested allergens at the age of 4 or as a 
      positive skin prick test to any of the six tested allergens at the age of 6. 
      McCarthy Scales of Child Abilities and California Preschool Social Competence 
      Scale were the psychometric instruments used. RESULTS: Twelve percent of children 
      at the age of 4 and 17% at the age of 6 were atopic. Neurobehavioral scores were 
      negatively associated with 6-year-old atopy after adjustment for 
      socio-demographic and allergic factors, A relative risk of 3.06 (95% CI: 
      1.30-7.24) was associated with the lowest tertile (scorings < or =90 points) of 
      the general cognitive scale. Similar results were found for verbal abilities, 
      executive functions, and social competence. Asthma, wheezing, rhinitis, and 
      eczema at the age of 6, but not at the age of 4, were associated with 
      neurodevelopment at the age of 4. CONCLUSIONS: Neuropsychologic functioning and 
      later atopy are negatively associated in preschool age children.
FAU - Julvez, J
AU  - Julvez J
AD  - Centre for Research in Environmental Epidemiology, Barcelona, Spain.
FAU - Torrent, M
AU  - Torrent M
FAU - Guxens, M
AU  - Guxens M
FAU - Anto, J M
AU  - Anto JM
FAU - Guerra, S
AU  - Guerra S
FAU - Sunyer, J
AU  - Sunyer J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090216
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - *Behavior
MH  - Child
MH  - *Child Development
MH  - Child, Preschool
MH  - *Cognition
MH  - Cohort Studies
MH  - Humans
MH  - Hypersensitivity/*epidemiology/immunology/*psychology
MH  - Immunoglobulin E/blood/*immunology
MH  - Neuropsychological Tests
MH  - Skin Tests
EDAT- 2009/02/25 09:00
MHDA- 2010/01/07 06:00
CRDT- 2009/02/25 09:00
PHST- 2009/02/25 09:00 [entrez]
PHST- 2009/02/25 09:00 [pubmed]
PHST- 2010/01/07 06:00 [medline]
AID - ALL1987 [pii]
AID - 10.1111/j.1398-9995.2009.01987.x [doi]
PST - ppublish
SO  - Allergy. 2009 Sep;64(9):1279-85. doi: 10.1111/j.1398-9995.2009.01987.x. Epub 2009 
      Feb 16.