PMID- 19236330
OWN - NLM
STAT- MEDLINE
DCOM- 20090325
LR  - 20090224
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1153
DP  - 2009 Feb
TI  - Cytokine-induced suppression of medial preoptic neurons: mechanisms and 
      neuroimmunomodulatory effects.
PG  - 76-81
LID - 10.1111/j.1749-6632.2008.03963.x [doi]
AB  - We have shown that the medial preoptic area (MPO) in the hypothalamus is a major 
      site where interferon (IFN)-alpha acts to induce suppression of splenic natural 
      killer (NK) cell activity through an activation of sympathetic nervous system 
      (SNS) in rats. Here, we discuss the hypothalamic mechanisms of the cytokine 
      action using in vivo and in vitro preparations in rats. Lesion of the MPO 
      activated the SNS and suppressed splenic NK cell activity in anesthetized rats, 
      suggesting that the MPO had an inhibitory influence on nerve activity. Since both 
      IFN-alpha and interleukin (IL)-1beta are known to suppress MPO neuron activity, 
      it is suggested that the suppression/loss of the MPO caused by cytokine 
      actions/lesions disinhibits the hypothalamic-sympathetic pathway, thereby 
      resulting in an increase in the splenic SNS and reduction of NK activity. To 
      explore the cellular mechanisms of the suppression of MPO neurons, the effects of 
      Prostaglandin E2 (PGE2), one of the major mediators of cytokine action in the 
      brain, on the glutamate-induced membrane currents were examined using the 
      perforated patch-clamp method in mechanically dissociated MPO neurons. 
      Patch-clamp analysis revealed that PGE2 potentiated the Ca2+-dependent K+ current 
      (KCa) stimulated by Ca2+ entry through N-methyl-D-aspartate channels. We suggest 
      that the cytokine-induced decrease in the firing rates of MPO neurons may be a 
      result of an increase in interspike intervals caused by PGE(2)-induced 
      enhancement of KCa in the presence of glutamatergic inputs.
FAU - Katafuchi, Toshihiko
AU  - Katafuchi T
AD  - Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, Japan. kataf@physiol.med.kyushu-u.ac.jp
FAU - Duan, Shumin
AU  - Duan S
FAU - Take, Sachiko
AU  - Take S
FAU - Yoshimura, Megumu
AU  - Yoshimura M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Cytokines)
RN  - 0 (Immunologic Factors)
RN  - 0 (Neurotransmitter Agents)
SB  - IM
MH  - Animals
MH  - Cytokines/*pharmacology
MH  - Humans
MH  - Immunologic Factors/*metabolism
MH  - Killer Cells, Natural/drug effects/metabolism
MH  - Neurons/*drug effects/*metabolism
MH  - Neurotransmitter Agents/*metabolism
MH  - Preoptic Area/*cytology/metabolism
RF  - 27
EDAT- 2009/02/25 09:00
MHDA- 2009/03/26 09:00
CRDT- 2009/02/25 09:00
PHST- 2009/02/25 09:00 [entrez]
PHST- 2009/02/25 09:00 [pubmed]
PHST- 2009/03/26 09:00 [medline]
AID - NYAS03963 [pii]
AID - 10.1111/j.1749-6632.2008.03963.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2009 Feb;1153:76-81. doi: 10.1111/j.1749-6632.2008.03963.x.