PMID- 19236729
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20221207
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Linking)
VI  - 12
IP  - 7
DP  - 2009 Aug
TI  - Synergistic neurochemical and behavioural effects of acute intrahippocampal 
      injection of brain-derived neurotrophic factor and antidepressants in adult mice.
PG  - 905-15
LID - 10.1017/S1461145709000017 [doi]
AB  - Preclinical data support the view that brain-derived neurotrophic factor (BDNF) 
      and serotonergic systems regulate circuits involved in affective disorders. The 
      present study examined neurochemical and behavioural consequences of an acute 
      intrahippocampal injection of BDNF combined with an antidepressant by using 
      in-vivo intracerebral microdialysis in the ventral hippocampus (vHi) in conscious 
      mice and behavioural paradigms predictive of antidepressant and anxiolytic-like 
      effects [the mouse forced swim test (FST), the open-field (OF) paradigm and the 
      elevated plus maze (EPM)]. Neurochemical data revealed that BDNF (100 ng) 
      potentiated the effects of the systemic administration of a serotonin selective 
      reuptake inhibitor (SSRI; paroxetine 4 mg/kg i.p.) and that of a locally applied 
      citalopram perfusion on dialysate 5-HT levels in the vHi. These neurochemical 
      changes correlated with behavioural data since, in the FST, antidepressant-like 
      activity of paroxetine as measured on swimming behaviour was potentiated by BDNF. 
      These data suggest an interesting synergy between BDNF and SSRI on 
      antidepressant-like activity. Furthermore, in both the OF and EPM paradigms BDNF 
      induced an anxiogenic-like activity, whereas paroxetine prevented this effect. 
      Finally, the neurochemical and behavioural effects of BDNF on the serotonergic 
      system might occur at both pre- and post-synaptic levels since by using in-situ 
      hybridization, we showed that TrkB-R mRNA was expressed in the hippocampus and 
      the dorsal raphe nucleus in adult mice. Taken together the neurochemical and 
      behavioural effects of BDNF suggest that these behavioural changes were mediated 
      by increases in 5-HT neurotransmission in vHi. Thus a BDNF+SSRI combination may 
      offer new alternatives to treat mood disorders.
FAU - Deltheil, Thierry
AU  - Deltheil T
AD  - Universite Paris-Sud, EA 3544, Faculte de Pharmacie, Chatenay-Malabry, France.
FAU - Tanaka, Kenji
AU  - Tanaka K
FAU - Reperant, Christelle
AU  - Reperant C
FAU - Hen, Rene
AU  - Hen R
FAU - David, Denis J
AU  - David DJ
FAU - Gardier, Alain M
AU  - Gardier AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090223
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 0DHU5B8D6V (Citalopram)
RN  - 333DO1RDJY (Serotonin)
RN  - 41VRH5220H (Paroxetine)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Antidepressive Agents/*administration & dosage
MH  - Anxiety/chemically induced/metabolism/prevention & control/psychology
MH  - Behavior, Animal/*drug effects
MH  - Brain-Derived Neurotrophic Factor/*administration & dosage/toxicity
MH  - Citalopram/*administration & dosage
MH  - Depression/*drug therapy/metabolism/physiopathology/psychology
MH  - Disease Models, Animal
MH  - Drug Synergism
MH  - Hippocampus/*drug effects/metabolism/physiopathology
MH  - In Situ Hybridization
MH  - Male
MH  - Mice
MH  - Microdialysis
MH  - Microinjections
MH  - Motor Activity/drug effects
MH  - Paroxetine/*administration & dosage
MH  - RNA, Messenger/metabolism
MH  - Receptor, trkB/drug effects/genetics
MH  - Serotonin/metabolism
MH  - Selective Serotonin Reuptake Inhibitors/*administration & dosage
MH  - Time Factors
EDAT- 2009/02/25 09:00
MHDA- 2011/09/07 06:00
CRDT- 2009/02/25 09:00
PHST- 2009/02/25 09:00 [entrez]
PHST- 2009/02/25 09:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
AID - S1461145709000017 [pii]
AID - 10.1017/S1461145709000017 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2009 Aug;12(7):905-15. doi: 
      10.1017/S1461145709000017. Epub 2009 Feb 23.