PMID- 19236730
OWN - NLM
STAT- MEDLINE
DCOM- 20100323
LR  - 20220409
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Linking)
VI  - 13
IP  - 1
DP  - 2010 Feb
TI  - Brain-derived neurotrophic factor ( BDNF) gene: no major impact on antidepressant 
      treatment response.
PG  - 93-101
LID - 10.1017/S1461145709000030 [doi]
AB  - The brain-derived neurotrophic factor (BDNF) has been suggested to play a pivotal 
      role in the aetiology of affective disorders. In order to further clarify the 
      impact of BDNF gene variation on major depression as well as antidepressant 
      treatment response, association of three BDNF polymorphisms [rs7103411, Val66Met 
      (rs6265) and rs7124442] with major depression and antidepressant treatment 
      response was investigated in an overall sample of 268 German patients with major 
      depression and 424 healthy controls. False discovery rate (FDR) was applied to 
      control for multiple testing. Additionally, ten markers in BDNF were tested for 
      association with citalopram outcome in the STAR*D sample. While BDNF was not 
      associated with major depression as a categorical diagnosis, the BDNF rs7124442 
      TT genotype was significantly related to worse treatment outcome over 6 wk in 
      major depression (p = 0.01) particularly in anxious depression (p = 0.003) in the 
      German sample. However, BDNF rs7103411 and rs6265 similarly predicted worse 
      treatment response over 6 wk in clinical subtypes of depression such as 
      melancholic depression only (rs7103411: TT < CC, p = 0.003; rs6265: GG < AA, p = 
      0.001). All SNPs had main effects on antidepressant treatment response in ANOVA 
      models when the remaining SNPs were considered as covariates. The STAR*D analyses 
      did not yield significant results at any of the ten BDNF markers. Our results do 
      not support an association between genetic variation in BDNF and antidepressant 
      treatment response or remission. Post-hoc analyses provide some preliminary 
      support for a potential minor role of genetic variation in BDNF and 
      antidepressant treatment outcome in the context of melancholic depression.
FAU - Domschke, Katharina
AU  - Domschke K
AD  - Department of Psychiatry, University of Muenster, Germany.
FAU - Lawford, Bruce
AU  - Lawford B
FAU - Laje, Gonzalo
AU  - Laje G
FAU - Berger, Klaus
AU  - Berger K
FAU - Young, Ross
AU  - Young R
FAU - Morris, Phillip
AU  - Morris P
FAU - Deckert, Jurgen
AU  - Deckert J
FAU - Arolt, Volker
AU  - Arolt V
FAU - McMahon, Francis J
AU  - McMahon FJ
FAU - Baune, Bernhard T
AU  - Baune BT
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20090223
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Antidepressive Agents/*therapeutic use
MH  - Anxiety/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Depressive Disorder, Major/diagnosis/drug therapy/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Treatment Outcome
EDAT- 2009/02/25 09:00
MHDA- 2010/03/24 06:00
CRDT- 2009/02/25 09:00
PHST- 2009/02/25 09:00 [entrez]
PHST- 2009/02/25 09:00 [pubmed]
PHST- 2010/03/24 06:00 [medline]
AID - S1461145709000030 [pii]
AID - 10.1017/S1461145709000030 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2010 Feb;13(1):93-101. doi: 
      10.1017/S1461145709000030. Epub 2009 Feb 23.