PMID- 19236854
OWN - NLM
STAT- MEDLINE
DCOM- 20090513
LR  - 20231213
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1265
DP  - 2009 Apr 10
TI  - Memantine treatment reduces the expression of the K(+)/Cl(-) cotransporter KCC2 
      in the hippocampus and cerebral cortex, and attenuates behavioural responses 
      mediated by GABA(A) receptor activation in mice.
PG  - 75-9
LID - 10.1016/j.brainres.2009.02.016 [doi]
AB  - A 7-day treatment with memantine (25 mg/kg, i.p.), a drug that is currently 
      prescribed for the treatment of Alzheimer's disease, increased the levels of 
      brain-derived neurotrophic factor (BDNF) and reduced the expression of the 
      neuron-specific K(+)/Cl(-) co-transporter, KCC2, in the hippocampus and cerebral 
      cortex of mice. Knowing that KCC2 maintains low intracellular Cl(-) 
      concentrations, which drive Cl(-) influx in response to GABA(A) receptor 
      activation, we monitored the behavioural response to the GABA(A) receptor 
      enhancer, diazepam, in mice pre-treated for 7 days with saline or 25 mg/kg of 
      memantine. Memantine treatment substantially attenuated motor impairment induced 
      by an acute challenge with diazepam (6 mg/kg, i.p.), as assessed by the rotarod 
      test and the horizontal wire test. We suggest that a prolonged treatment with 
      memantine induces changes in the activity of GABA(A) receptors that might 
      contribute to the therapeutic and/or toxic effects of the drug.
FAU - Molinaro, Gemma
AU  - Molinaro G
AD  - I.N.M. Neuromed, Pozzilli, Italy.
FAU - Battaglia, Giuseppe
AU  - Battaglia G
FAU - Riozzi, Barbara
AU  - Riozzi B
FAU - Di Menna, Luisa
AU  - Di Menna L
FAU - Rampello, Liborio
AU  - Rampello L
FAU - Bruno, Valeria
AU  - Bruno V
FAU - Nicoletti, Ferdinando
AU  - Nicoletti F
LA  - eng
PT  - Journal Article
DEP - 20090221
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (GABA Modulators)
RN  - 0 (GABA-A Receptor Agonists)
RN  - 0 (Symporters)
RN  - Q3JTX2Q7TU (Diazepam)
RN  - W8O17SJF3T (Memantine)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cerebral Cortex/drug effects/*metabolism
MH  - Diazepam/administration & dosage/*pharmacology
MH  - Excitatory Amino Acid Antagonists/administration & dosage/*pharmacology
MH  - GABA Modulators/*pharmacology
MH  - GABA-A Receptor Agonists
MH  - Hippocampus/drug effects/*metabolism
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Memantine/administration & dosage/*pharmacology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Motor Activity/*drug effects/physiology
MH  - Rotarod Performance Test/methods
MH  - Symporters/*metabolism
MH  - K Cl- Cotransporters
EDAT- 2009/02/25 09:00
MHDA- 2009/05/14 09:00
CRDT- 2009/02/25 09:00
PHST- 2009/01/02 00:00 [received]
PHST- 2009/02/06 00:00 [revised]
PHST- 2009/02/11 00:00 [accepted]
PHST- 2009/02/25 09:00 [entrez]
PHST- 2009/02/25 09:00 [pubmed]
PHST- 2009/05/14 09:00 [medline]
AID - S0006-8993(09)00336-9 [pii]
AID - 10.1016/j.brainres.2009.02.016 [doi]
PST - ppublish
SO  - Brain Res. 2009 Apr 10;1265:75-9. doi: 10.1016/j.brainres.2009.02.016. Epub 2009 
      Feb 21.