PMID- 19236899
OWN - NLM
STAT- MEDLINE
DCOM- 20090619
LR  - 20211020
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 70
IP  - 5
DP  - 2009 May
TI  - Understanding human myeloid dendritic cell subsets for the rational design of 
      novel vaccines.
PG  - 281-8
LID - 10.1016/j.humimm.2009.02.004 [doi]
AB  - Dendritic cells (DCs) orchestrate a repertoire of immune responses that endows 
      resistance to infection and tolerance to self. Understanding the principles by 
      which DCs control immunity and tolerance has provided a rich basis for studying 
      and improving clinical outcome of human disease treatment. Several features 
      contribute to the complexity of the DC system. Among these, plasticity and 
      existence of subsets are prominent determinants to the quality of the elicited 
      immune responses. Indeed, different DC subsets are distributed in peripheral 
      tissues and the blood and display different microbial receptors, surface 
      molecules and cytokine expression, all of which influence the immunologic 
      outcome. The biologic raison d'etre for separate DC subsets has been the focus of 
      many studies including our own and is being reviewed with an emphasis on human 
      skin DCs.
FAU - Klechevsky, Eynav
AU  - Klechevsky E
AD  - Baylor Institute for Immunology Research, Dallas, Texas, USA.
FAU - Liu, Maochang
AU  - Liu M
FAU - Morita, Rimpei
AU  - Morita R
FAU - Banchereau, Romain
AU  - Banchereau R
FAU - Thompson-Snipes, Luann
AU  - Thompson-Snipes L
FAU - Palucka, A Karolina
AU  - Palucka AK
FAU - Ueno, Hideki
AU  - Ueno H
FAU - Banchereau, Jacques
AU  - Banchereau J
LA  - eng
GR  - U19 AI057234-010005/AI/NIAID NIH HHS/United States
GR  - U19 AI057234-04/AI/NIAID NIH HHS/United States
GR  - P01 CA084512-030003/CA/NCI NIH HHS/United States
GR  - P01 CA084512-020003/CA/NCI NIH HHS/United States
GR  - R01 CA078846-07/CA/NCI NIH HHS/United States
GR  - R01 CA078846-08/CA/NCI NIH HHS/United States
GR  - U19 AI057234-05/AI/NIAID NIH HHS/United States
GR  - P01 CA084512/CA/NCI NIH HHS/United States
GR  - R01 CA078846-10/CA/NCI NIH HHS/United States
GR  - R01 CA078846-01A1/CA/NCI NIH HHS/United States
GR  - R01 CA078846-09/CA/NCI NIH HHS/United States
GR  - U19 AI057234-05S1/AI/NIAID NIH HHS/United States
GR  - R01 CA078846-02/CA/NCI NIH HHS/United States
GR  - U19 AI057234/AI/NIAID NIH HHS/United States
GR  - U19 AI057234-010004/AI/NIAID NIH HHS/United States
GR  - U19 AI057234-03/AI/NIAID NIH HHS/United States
GR  - U19 AI057234-02/AI/NIAID NIH HHS/United States
GR  - U19 AI057234-05S10012/AI/NIAID NIH HHS/United States
GR  - P01 CA084512-060005/CA/NCI NIH HHS/United States
GR  - R01 CA078846-04/CA/NCI NIH HHS/United States
GR  - U19 AI057234-01/AI/NIAID NIH HHS/United States
GR  - P01 CA084512-01A10003/CA/NCI NIH HHS/United States
GR  - P01 CA084512-05A2/CA/NCI NIH HHS/United States
GR  - R01 CA078846-05/CA/NCI NIH HHS/United States
GR  - P01 CA084512-06/CA/NCI NIH HHS/United States
GR  - R01 CA078846-06/CA/NCI NIH HHS/United States
GR  - R01 CA078846-03/CA/NCI NIH HHS/United States
GR  - R01 CA078846/CA/NCI NIH HHS/United States
GR  - P01 CA084512-070005/CA/NCI NIH HHS/United States
GR  - P01 CA084512-07/CA/NCI NIH HHS/United States
GR  - P01 CA084512-040003/CA/NCI NIH HHS/United States
GR  - P01 CA084512-05A20005/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20090221
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antigens, CD1)
RN  - 0 (CD1a antigen)
RN  - 0 (Cytokines)
RN  - 0 (Vaccines)
SB  - IM
MH  - Animals
MH  - Antibody Formation/immunology
MH  - Antigens, CD1/immunology
MH  - CD4-Positive T-Lymphocytes/immunology/metabolism
MH  - CD8-Positive T-Lymphocytes/immunology/metabolism
MH  - Cell Communication/immunology
MH  - Cytokines/*immunology/metabolism
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunity, Cellular/immunology
MH  - Mice
MH  - Vaccines/*immunology
PMC - PMC2674516
MID - NIHMS99968
EDAT- 2009/02/25 09:00
MHDA- 2009/06/20 09:00
PMCR- 2010/05/01
CRDT- 2009/02/25 09:00
PHST- 2009/01/29 00:00 [received]
PHST- 2009/02/10 00:00 [revised]
PHST- 2009/02/11 00:00 [accepted]
PHST- 2009/02/25 09:00 [entrez]
PHST- 2009/02/25 09:00 [pubmed]
PHST- 2009/06/20 09:00 [medline]
PHST- 2010/05/01 00:00 [pmc-release]
AID - S0198-8859(09)00044-5 [pii]
AID - 10.1016/j.humimm.2009.02.004 [doi]
PST - ppublish
SO  - Hum Immunol. 2009 May;70(5):281-8. doi: 10.1016/j.humimm.2009.02.004. Epub 2009 
      Feb 21.