PMID- 19236907
OWN - NLM
STAT- MEDLINE
DCOM- 20091021
LR  - 20240312
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 160
IP  - 2
DP  - 2009 May 5
TI  - Sensitizing regimens of (+/-)3, 4-methylenedioxymethamphetamine (ecstasy) elicit 
      enduring and differential structural alterations in the brain motive circuit of 
      the rat.
PG  - 264-74
LID - 10.1016/j.neuroscience.2009.02.025 [doi]
AB  - Repeated, intermittent exposure to the psychomotor stimulants amphetamine and 
      cocaine induces a progressive and enduring augmentation of their 
      locomotor-activating effects, known as behavioral sensitization, which is 
      accompanied by similarly stable adaptations in the dendritic structure of 
      cortico-striatal neurons. We examined whether repeated exposure to the 
      increasingly abused amphetamine derivative 3,4-methylenedioxymethamphetamine 
      (MDMA; ecstasy) also results in long-lasting behavioral and morphological changes 
      in mesocortical (medial prefrontal cortex) and ventral striatal (nucleus 
      accumbens) neurons. Rats received two daily injections of either 5.0 mg/kg 
      (+/-)-MDMA or saline vehicle, approximately 6 h apart, for 3 consecutive days, 
      followed by 4 drug-free days for a total of 3 weeks. Following a 4-week drug-free 
      period, MDMA-pretreated rats displayed behavioral sensitization, as well as large 
      increases in spine density and the number of multiple-headed spines on medium 
      spiny neurons in core and shell subregions of nucleus accumbens. In medial 
      prefrontal cortex, the prelimbic subregion showed increased spine density on 
      distal dendrites of layer V pyramidal neurons, while the anterior cingulate 
      subregion showed a change in the distribution of dendritic material instead. 
      Collectively, our results show that long-lasting locomotor sensitization to MDMA 
      is accompanied by reorganization of synaptic connectivity in 
      limbic-cortico-striatal circuitry. The differential plasticity in cortical 
      subregions, moreover, suggests that drug-induced structural changes are not 
      homogeneous and may be specific to the circuitry underlying long-term changes in 
      drug-seeking and drug-taking behavior.
FAU - Ball, K T
AU  - Ball KT
AD  - Department of Psychology, Bloomsburg University of Pennsylvania, 400 East Second 
      Street, Bloomsburg, PA 17815-1301, USA.
FAU - Wellman, C L
AU  - Wellman CL
FAU - Fortenberry, E
AU  - Fortenberry E
FAU - Rebec, G V
AU  - Rebec GV
LA  - eng
GR  - DA 02451/DA/NIDA NIH HHS/United States
GR  - F31 DA020209/DA/NIDA NIH HHS/United States
GR  - R01 DA002451/DA/NIDA NIH HHS/United States
GR  - R01 DA002451-24/DA/NIDA NIH HHS/United States
GR  - DA 020209/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090221
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adaptation, Physiological/drug effects
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Cerebrum/cytology/*drug effects
MH  - Dendritic Spines/*drug effects
MH  - Drug Administration Schedule
MH  - Gyrus Cinguli/cytology/drug effects
MH  - Hallucinogens/*administration & dosage/pharmacology
MH  - Male
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage/pharmacology
MH  - Neural Pathways/drug effects
MH  - Neuronal Plasticity/*drug effects
MH  - Nucleus Accumbens/cytology/drug effects
MH  - Prefrontal Cortex/cytology/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Synaptic Transmission/drug effects
PMC - PMC2669702
MID - NIHMS97470
EDAT- 2009/02/25 09:00
MHDA- 2009/10/22 06:00
PMCR- 2010/05/05
CRDT- 2009/02/25 09:00
PHST- 2008/12/11 00:00 [received]
PHST- 2009/02/05 00:00 [revised]
PHST- 2009/02/07 00:00 [accepted]
PHST- 2009/02/25 09:00 [entrez]
PHST- 2009/02/25 09:00 [pubmed]
PHST- 2009/10/22 06:00 [medline]
PHST- 2010/05/05 00:00 [pmc-release]
AID - S0306-4522(09)00193-6 [pii]
AID - 10.1016/j.neuroscience.2009.02.025 [doi]
PST - ppublish
SO  - Neuroscience. 2009 May 5;160(2):264-74. doi: 10.1016/j.neuroscience.2009.02.025. 
      Epub 2009 Feb 21.