PMID- 19236988
OWN - NLM
STAT- MEDLINE
DCOM- 20090325
LR  - 20220410
IS  - 1532-821X (Electronic)
IS  - 0003-9993 (Linking)
VI  - 90
IP  - 2
DP  - 2009 Feb
TI  - Attenuated skin blood flow response to nociceptive stimulation of latent 
      myofascial trigger points.
PG  - 325-32
LID - 10.1016/j.apmr.2008.06.037 [doi]
AB  - OBJECTIVES: To investigate the effect of painful stimulation of latent myofascial 
      trigger points (MTrPs) on skin blood flow and to evaluate the relative 
      sensitivity of laser Doppler flowmetry (LDF) and thermography in the measurement 
      of skin blood flow. DESIGN: Painful stimulation was obtained by a bolus injection 
      of glutamate (0.1mL, 0.5M) into a latent MTrP located in the right or left 
      brachioradialis muscles. A bolus of glutamate injection into a non-MTrP served as 
      control. Pain intensity (visual analog scale [VAS]) was assessed after glutamate 
      injection. Pressure pain threshold (PPT) was recorded bilaterally in the 
      brachioradialis muscle before and after glutamate-induced pain. Skin blood flow 
      and surface skin temperature were measured bilaterally in the forearms before, 
      during, and after glutamate-induced pain with LDF and thermography. SETTING: A 
      biomedical research facility. PARTICIPANTS: Fifteen healthy volunteer subjects. 
      INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: VAS, PPT, skin blood flow, 
      and surface skin temperature. RESULTS: Glutamate injection into latent MTrPs 
      induced higher pain intensity (F=7.16; P<.05) and lower PPT (F=11.41, P<.005) 
      than into non-MTrPs. Glutamate injection into non-MTrPs increased skin blood flow 
      bilaterally in the forearms, but skin blood flow after glutamate injection into 
      latent MTrPs was significantly less increased at the local injection area or 
      decreased at distant areas compared with non-MTrPs (all P<.05). Skin temperature 
      was not affected after glutamate injection into either latent MTrPs or non-MTrPs 
      (all P>.05). CONCLUSIONS: The present study demonstrated an attenuated skin blood 
      flow response after painful stimulation of latent MTrPs compared with non-MTrPs, 
      suggesting increased sympathetic vasoconstriction activity at latent MTrPs. 
      Additionally, LDF was more sensitive than thermography in the detection of the 
      changes in skin blood flow after intramuscular nociceptive stimulation.
FAU - Zhang, Yang
AU  - Zhang Y
AD  - Laboratory for Experimental Pain Research, Center for Sensory-Motor Interaction, 
      Department of Health Science and Technology, Aalborg University, Aalborg, 
      Denmark.
FAU - Ge, Hong-You
AU  - Ge HY
FAU - Yue, Shou-Wei
AU  - Yue SW
FAU - Kimura, Yoshiyuki
AU  - Kimura Y
FAU - Arendt-Nielsen, Lars
AU  - Arendt-Nielsen L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Phys Med Rehabil
JT  - Archives of physical medicine and rehabilitation
JID - 2985158R
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Adult
MH  - Female
MH  - Glutamic Acid
MH  - Humans
MH  - Male
MH  - Myofascial Pain Syndromes/*physiopathology
MH  - Pain/*chemically induced/*physiopathology
MH  - Pain Measurement
MH  - Pain Threshold
MH  - Skin/*blood supply
MH  - Skin Temperature
MH  - Stimulation, Chemical
EDAT- 2009/02/25 09:00
MHDA- 2009/03/26 09:00
CRDT- 2009/02/25 09:00
PHST- 2008/04/23 00:00 [received]
PHST- 2008/06/27 00:00 [revised]
PHST- 2008/06/30 00:00 [accepted]
PHST- 2009/02/25 09:00 [entrez]
PHST- 2009/02/25 09:00 [pubmed]
PHST- 2009/03/26 09:00 [medline]
AID - S0003-9993(08)01602-X [pii]
AID - 10.1016/j.apmr.2008.06.037 [doi]
PST - ppublish
SO  - Arch Phys Med Rehabil. 2009 Feb;90(2):325-32. doi: 10.1016/j.apmr.2008.06.037.