PMID- 19237165
OWN - NLM
STAT- MEDLINE
DCOM- 20090810
LR  - 20111117
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 280
IP  - 1-2
DP  - 2009 May 15
TI  - Serial cerebrospinal fluid neurofilament concentrations in bacterial meningitis.
PG  - 59-61
LID - 10.1016/j.jns.2009.01.021 [doi]
AB  - Neurofilament (NF) is one of the major cytoskeleton proteins of neurons. We 
      investigated the concentrations of the heavy subunit of NF (NF-H) in 
      cerebrospinal fluid (CSF) as biomarkers of neuronal injury in bacterial 
      meningitis. Concentrations of NF-H in CSF of 26 children with bacterial 
      meningitis and in 16 control subjects were measured by ELISA. The CSF NF-H levels 
      were elevated in 22 of the 26 children (85%) with bacterial meningitis. The peak 
      CSF NF-H level occurred at a median period of 10.5 days after onset of illness 
      (range, 1 to 35 days). The peak CSF NF-H levels of the patients with neurological 
      sequelae (n=4) were significantly higher than those without sequelae (n=22) (7.06 
      vs. 2.46 ng/mL as median, p=0.048). There was no significant difference in CSF 
      NF-H levels between patients with and without severe neurological sequelae up to 
      day 14 of illness, but the CSF NF-H levels in patients with sequelae were 
      significantly higher than in those without sequelae after day 14 of illness (2.04 
      vs. 1.19 ng/mL as median, p=0.024). We suggest that neuronal injury occurs in 
      bacterial meningitis regardless of the presence or absence of neurological 
      sequelae.
FAU - Matsushige, Takeshi
AU  - Matsushige T
AD  - Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 
      Yamaguchi, Japan.
FAU - Ichiyama, Takashi
AU  - Ichiyama T
FAU - Kajimoto, Madoka
AU  - Kajimoto M
FAU - Okuda, Masayuki
AU  - Okuda M
FAU - Fukunaga, Shinnosuke
AU  - Fukunaga S
FAU - Furukawa, Susumu
AU  - Furukawa S
LA  - eng
PT  - Journal Article
DEP - 20090223
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Neurofilament Proteins)
SB  - IM
MH  - Child, Preschool
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Hearing Loss, Sensorineural/cerebrospinal fluid/complications
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Intellectual Disability/cerebrospinal fluid/complications
MH  - Male
MH  - Meningitis, Bacterial/*cerebrospinal fluid/complications
MH  - Meningitis, Escherichia coli/cerebrospinal fluid/complications
MH  - Meningitis, Haemophilus/cerebrospinal fluid/complications
MH  - Meningitis, Pneumococcal/cerebrospinal fluid/complications
MH  - Methicillin-Resistant Staphylococcus aureus
MH  - Neurofilament Proteins/*cerebrospinal fluid
MH  - Paresis/cerebrospinal fluid/complications
MH  - Time Factors
EDAT- 2009/02/25 09:00
MHDA- 2009/08/11 09:00
CRDT- 2009/02/25 09:00
PHST- 2008/10/20 00:00 [received]
PHST- 2009/01/09 00:00 [revised]
PHST- 2009/01/28 00:00 [accepted]
PHST- 2009/02/25 09:00 [entrez]
PHST- 2009/02/25 09:00 [pubmed]
PHST- 2009/08/11 09:00 [medline]
AID - S0022-510X(09)00048-3 [pii]
AID - 10.1016/j.jns.2009.01.021 [doi]
PST - ppublish
SO  - J Neurol Sci. 2009 May 15;280(1-2):59-61. doi: 10.1016/j.jns.2009.01.021. Epub 
      2009 Feb 23.