PMID- 19238441
OWN - NLM
STAT- MEDLINE
DCOM- 20090706
LR  - 20211020
IS  - 1432-1955 (Electronic)
IS  - 0932-0113 (Linking)
VI  - 105
IP  - 1
DP  - 2009 Jul
TI  - Study on acute phase proteins (haptoglobin, serum amyloid A, fibrinogen, and 
      ceruloplasmin) changes and their diagnostic values in bovine tropical 
      theileriosis.
PG  - 41-6
LID - 10.1007/s00436-009-1360-x [doi]
AB  - This study was conducted to assess the pattern of changes and the relative value 
      of acute phase proteins (haptoglobin (Hp), serum amyloid A (SAA), ceruloplasmin 
      and fibrinogen) in bovine tropical theileriosis. The diseased group comprised 50 
      dairy Holstein cattle, 2-3 years old, naturally infected with Theileria annulata. 
      Infected animals were divided into four subgroups with different parasitemia 
      rates (<1%, 1-3%, 3-5%, >5%). As a control group, 20 uninfected cattle were also 
      sampled. Blood samples were collected and all measurements were done using 
      validated methods. There were significant differences in red blood cells (RBCs), 
      packed cell volume (PCV), hemoglobin (Hb) and concentrations of Hp, SAA, 
      ceruloplasmin and fibrinogen between healthy cattle and those infected with T. 
      annulata with different parasitemia rates (P < 0.05). As the parasitemia rate 
      increased in infected cattle, a significant decrease was observed in RBCs, PCV, 
      and Hb. In contrast, with increase in the parasitemia rate, a significant 
      increase in the mean corpuscular volume (MCV), mean corpuscular hemoglobin 
      concentration (MCHC), Hp, SAA, ceruloplasmin, and fibrinogen was evident. The 
      optimal cut-off point was set by the receiver operating characteristics (ROC) 
      method to >5.68 microg/ml for SAA, >0.16 g/l for Hp, >0.064 g/l for ceruloplasmin 
      and >4.00 g/l for fibrinogen with corresponding 84% sensitivity and 100% 
      specificity for SAA, 76% sensitivity and 100% specificity for Hp, 84% sensitivity 
      and 80% specificity for ceruloplasmin and 40% sensitivity and 100% specificity 
      for fibrinogen. SAA had the highest sensitivity and specificity and was diagnosed 
      to be a suitable indicator of APPs changes in bovine theileriosis.
FAU - Nazifi, S
AU  - Nazifi S
AD  - Department of Clinical Studies, Shiraz University, Iran. nazifi@shirazu.ac.ir
FAU - Razavi, S M
AU  - Razavi SM
FAU - Esmailnejad, Z
AU  - Esmailnejad Z
FAU - Gheisari, H
AU  - Gheisari H
LA  - eng
PT  - Journal Article
DEP - 20090224
PL  - Germany
TA  - Parasitol Res
JT  - Parasitology research
JID - 8703571
RN  - 0 (Acute-Phase Proteins)
SB  - IM
MH  - Acute-Phase Proteins/*analysis
MH  - Animals
MH  - Cattle
MH  - Cattle Diseases/*diagnosis/pathology
MH  - Erythrocyte Count
MH  - Parasitemia
MH  - Sensitivity and Specificity
MH  - Theileria annulata/*isolation & purification
MH  - Theileriasis/*diagnosis/pathology
EDAT- 2009/02/25 09:00
MHDA- 2009/07/07 09:00
CRDT- 2009/02/25 09:00
PHST- 2008/07/14 00:00 [received]
PHST- 2009/01/23 00:00 [accepted]
PHST- 2009/02/25 09:00 [entrez]
PHST- 2009/02/25 09:00 [pubmed]
PHST- 2009/07/07 09:00 [medline]
AID - 10.1007/s00436-009-1360-x [doi]
PST - ppublish
SO  - Parasitol Res. 2009 Jul;105(1):41-6. doi: 10.1007/s00436-009-1360-x. Epub 2009 
      Feb 24.