PMID- 19240110
OWN - NLM
STAT- MEDLINE
DCOM- 20090528
LR  - 20220409
IS  - 1532-2092 (Electronic)
IS  - 1099-5129 (Linking)
VI  - 11
IP  - 3
DP  - 2009 Mar
TI  - Patients with non-ischaemic dilated cardiomyopathy and hyper-responders to 
      cardiac resynchronization therapy: characteristics and long-term evolution.
PG  - 350-5
LID - 10.1093/europace/eup035 [doi]
AB  - AIMS: In some patients with non-ischaemic dilated cardiomyopathy (NIDCM), left 
      bundle branch block (LBBB), and severe cardiac failure, cardiac resynchronization 
      therapy (CRT) has been shown to reverse almost completely left ventricular (LV) 
      function. These patients thus eligible to be qualified 'hyper-responders' are 
      exclusively recruited in patients with NIDCM. Evaluate proportion of 
      'hyper-responders' among patients with NIDCM and try to determine their profile 
      before implantation of CRT. METHODS AND RESULTS: Consecutive patients with DCM 
      [LV ejection fraction (LVEF) <35%, LV end-diastolic diameter >60 mm], sinus 
      rhythm, LBBB, and New York Heart Association (NYHA) class III and IV implanted 
      with a CRT were prospectively followed. Patients were considered 
      'hyper-responders' if they fulfilled after a minimum period of 6 months the 
      following criteria: functional recovery (NYHA class I or II) and LVEF >or=50%. 
      Among the 51 NIDCM patients, 11 (21.5%) were 'hyper-responders' following CRT 
      (LVEF increased from 26 +/- 9 to 59 +/- 6%, P < 0.01). In the 40 (78.5%) 
      remaining patients, there was no or minimal functional improvement and only a 
      modest increase in LVEF from 21 +/- 9 to 26 +/- 12% (P = 0.03). Comparison 
      between 'hyper-responders' and remaining patients showed that baseline parameters 
      of 'hyper-responders' were less severely deteriorated. CONCLUSION: In a 
      significant subset of patients with CRT for NIDCM, a 'complete' functional 
      recovery associated with normalization of LV function was observed. This 
      observation suggests that LBBB could be the causative factor of DCM in this 
      subgroup of patients. There was not a unique discriminating factor at baseline 
      between 'hyper-responders' and remaining patients.
FAU - Castellant, Philippe
AU  - Castellant P
AD  - Departement of Cardiology, Hopital de la Cavale Blanche, Brest University 
      Hospital, Bd Tanguy Prigent, 29609 Brest Cedex, France.
FAU - Fatemi, Marjaneh
AU  - Fatemi M
FAU - Orhan, Erwann
AU  - Orhan E
FAU - Etienne, Yves
AU  - Etienne Y
FAU - Blanc, Jean Jacques
AU  - Blanc JJ
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular 
      electrophysiology of the European Society of Cardiology
JID - 100883649
SB  - IM
MH  - Aged
MH  - Cardiac Pacing, Artificial/*mortality
MH  - Cardiomyopathy, Dilated/*mortality/*prevention & control
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Myocardial Ischemia/mortality/prevention & control
MH  - Survival Analysis
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2009/02/26 09:00
MHDA- 2009/05/29 09:00
CRDT- 2009/02/26 09:00
PHST- 2009/02/26 09:00 [entrez]
PHST- 2009/02/26 09:00 [pubmed]
PHST- 2009/05/29 09:00 [medline]
AID - eup035 [pii]
AID - 10.1093/europace/eup035 [doi]
PST - ppublish
SO  - Europace. 2009 Mar;11(3):350-5. doi: 10.1093/europace/eup035.