PMID- 19241322
OWN - NLM
STAT- MEDLINE
DCOM- 20090511
LR  - 20151119
IS  - 1438-9010 (Electronic)
IS  - 1438-9010 (Linking)
VI  - 181
IP  - 5
DP  - 2009 May
TI  - Prevalence, pattern, and functional impact of late gadolinium enhancement in left 
      ventricular hypertrophy due to aortic valve stenosis.
PG  - 472-6
LID - 10.1055/s-0028-1109044 [doi]
AB  - PURPOSE: To assess the prevalence and pattern of myocardial late gadolinium 
      enhancement (LGE) and its functional impact on patients with left ventricular 
      hypertrophy caused by aortic valve stenosis. MATERIALS AND METHODS: Cardiac 
      magnetic resonance imaging of 40 patients (17 female, 23 male, mean age: 76.6 +/- 
      22.5 years) with known aortic valve stenosis (mean aortic valve area: 89.8 +/- 
      19.2 mm(2)) and without coronary artery disease was performed at 1.5 T using 
      steady-state free precession sequences for aortic valve planimetry and for the 
      assessment of left ventricular (LV) volumes and mass. Ten to 15 minutes after 
      injection of 0.2 mmol Gd-DTPA per kilogram body weight, inversion-recovery 
      prepared spoiled gradient echo images were acquired in standard long and short 
      axis views to detect areas of LGE. RESULTS: LGE was observed in 32.5 % (13/40) of 
      our patients. LGE was mainly located in the basal septal and inferior LV 
      segments, and showed a non-ischemic pattern with sparing of the subendocardial 
      region. Patients with LGE showed lower LV ejection fractions (55.5 +/- 13.8 % vs. 
      69.1 +/- 10.7 %, p = 0.0014), higher LV end-systolic volumes (59.8 +/- 33.3 ml 
      vs. 36.6 +/- 16.0 ml, p = 0.0048), and LV masses (211.0 +/- 13.8 vs. 157.9 +/- 
      37.5 g, p = 0.0002) compared to patients without LGE. CONCLUSION: LGE is frequent 
      in patients with hypertrophic left ventricles due to aortic valve stenosis and is 
      associated with worse LV function.
FAU - Nassenstein, K
AU  - Nassenstein K
AD  - Abteilung fur Diagnostische und Interventionelle Radiologie, Universitatsklinikum 
      Essen, Essen. Kai.Nassenstein@uni-due.de
FAU - Bruder, O
AU  - Bruder O
FAU - Breuckmann, F
AU  - Breuckmann F
FAU - Erbel, R
AU  - Erbel R
FAU - Barkhausen, J
AU  - Barkhausen J
FAU - Schlosser, T
AU  - Schlosser T
LA  - eng
PT  - Journal Article
DEP - 20090224
PL  - Germany
TA  - Rofo
JT  - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
JID - 7507497
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Valve/pathology/physiopathology
MH  - Aortic Valve Stenosis/*diagnosis/physiopathology/surgery
MH  - Cardiac Volume/physiology
MH  - Contrast Media/*administration & dosage
MH  - Endocardium/pathology/physiopathology
MH  - Endomyocardial Fibrosis/diagnosis
MH  - Female
MH  - *Gadolinium DTPA
MH  - Heart Valve Prosthesis Implantation
MH  - Heart Ventricles/pathology/physiopathology
MH  - Humans
MH  - Hypertrophy, Left Ventricular/*diagnosis/surgery
MH  - *Image Enhancement
MH  - *Image Processing, Computer-Assisted
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardium/pathology
MH  - Prognosis
MH  - Stroke Volume/physiology
MH  - Ventricular Function, Left
MH  - Young Adult
EDAT- 2009/02/26 09:00
MHDA- 2009/05/12 09:00
CRDT- 2009/02/26 09:00
PHST- 2009/02/26 09:00 [entrez]
PHST- 2009/02/26 09:00 [pubmed]
PHST- 2009/05/12 09:00 [medline]
AID - 10.1055/s-0028-1109044 [doi]
PST - ppublish
SO  - Rofo. 2009 May;181(5):472-6. doi: 10.1055/s-0028-1109044. Epub 2009 Feb 24.