PMID- 19243130
OWN - NLM
STAT- MEDLINE
DCOM- 20090506
LR  - 20131121
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 57
IP  - 6
DP  - 2009 Mar 25
TI  - Residue depletion of imidocarb in Swine tissue.
PG  - 2324-8
LID - 10.1021/jf803251j [doi]
AB  - A residue depletion study was performed with high-performance liquid 
      chromatography (HPLC) to determine a withdrawal period of imidocarb (IMD) in 
      swine tissues. The drug was administered intramuscularly (im) at the dose of 2.0 
      mg kg(-1) of body weight (bw) once a day for 3 days. Samples of muscle, fat, 
      liver, kidney, and injection site muscle from 5 pigs were collected on 7, 14, 28, 
      and 56 days after the last administration. Quantitative analysis of IMD was 
      conducted by HPLC-UV at 260 nm after liquid-liquid extraction. The limit of 
      detection (LOD) of the method was 0.1 microg g(-1) for liver and kidney and 0.05 
      microg g(-1) for muscle and fat, respectively. Mean recoveries of IMD in all 
      fortified samples at a concentration range of 0.1-25 microg g(-1) were 
      69.5-89.3%, with a coefficient of variation (CV) below 13.3%. In swine, the 
      highest drug levels occurred in liver and kidney during the whole study period, 
      suggesting that these tissues are targets for residues. IMD concentrations in all 
      examined tissues were below the accepted maximum residue limits (MRLs) 
      recommended by the Committee for Veterinary Medical Products (CVMP) of the 
      European Medical Evaluation Agency (EMEA) at 54 days post-treatment.
FAU - Wang, Zhongjie
AU  - Wang Z
AD  - College of Veterinary Medicine, China Agricultural University, Beijing, People's 
      Republic of China.
FAU - Li, Xiubo
AU  - Li X
FAU - Su, Dan
AU  - Su D
FAU - Li, Yijing
AU  - Li Y
FAU - Wu, Lianyong
AU  - Wu L
FAU - Wang, Yongjian
AU  - Wang Y
FAU - Wu, Wenxue
AU  - Wu W
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Antiprotozoal Agents)
RN  - 8USS3K0VDH (Imidocarb)
SB  - IM
MH  - Adipose Tissue/chemistry
MH  - Animals
MH  - Antiprotozoal Agents/administration & dosage/analysis/*pharmacokinetics
MH  - Chromatography, High Pressure Liquid
MH  - Drug Residues/*analysis
MH  - Imidocarb/administration & dosage/analysis/*pharmacokinetics
MH  - Kidney/chemistry
MH  - Liver/chemistry
MH  - Maximum Allowable Concentration
MH  - Meat/*analysis
MH  - Muscles/chemistry
MH  - *Swine
EDAT- 2009/02/27 09:00
MHDA- 2009/05/07 09:00
CRDT- 2009/02/27 09:00
PHST- 2009/02/27 09:00 [entrez]
PHST- 2009/02/27 09:00 [pubmed]
PHST- 2009/05/07 09:00 [medline]
AID - 10.1021/jf803251j [doi]
PST - ppublish
SO  - J Agric Food Chem. 2009 Mar 25;57(6):2324-8. doi: 10.1021/jf803251j.