PMID- 19243623
OWN - NLM
STAT- MEDLINE
DCOM- 20091207
LR  - 20211020
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 8
DP  - 2009 Feb 25
TI  - Analysis of renin-angiotensin aldosterone system gene polymorphisms in Malaysian 
      essential hypertensive and type 2 diabetic subjects.
PG  - 11
LID - 10.1186/1475-2840-8-11 [doi]
AB  - BACKGROUND: The renin-angiotensin aldosterone system (RAAS) plays an important 
      role in regulating the blood pressure and the genetic polymorphisms of RAAS genes 
      has been extensively studied in relation to the cardiovascular diseases in 
      various populations with conflicting results. The aim of this study was to 
      determine the association of five genetic polymorphisms (A6G and A20C of 
      angiotensinogen (AGT), MboI of renin, Gly460Trp of aldosterone synthase and 
      Lys173Arg of adducin) of RAAS genes in Malaysian essential hypertensive and type 
      2 diabetic subjects. METHODS: RAAS gene polymorphisms were determined using 
      mutagenically separated PCR and PCR-RFLP method in a total of 270 subjects 
      consisting of 70 hypertensive subjects without type 2 diabetes mellitus (T2DM), 
      60 T2DM, 65 hypertensive subjects with T2DM and 75 control subjects. RESULTS: 
      There was significant difference found in age, body mass index, 
      systolic/diastolic blood pressure, fasting plasma glucose and high density 
      lipoprotein cholesterol levels between the hypertensive subjects with or without 
      T2DM and control subjects. No statistically significant differences between 
      groups were found in the allele frequency and genotype distribution for A20C 
      variant of AGT gene, MboI of renin, Gly460Trp of aldosterone and Lys173Arg of 
      adducin (p > 0.05). However, the results for A6G of AGT gene revealed significant 
      differences in allele and genotype frequencies in essential hypertension with or 
      without T2DM (p < 0.001). CONCLUSION: Among the five polymorphisms of RAAS genes 
      only A6G variant of AGT gene was significantly associated in Malaysian essential 
      hypertensive and type 2 diabetic subjects. Therefore, A6G polymorphism of the AGT 
      gene could be a potential genetic marker for increased susceptibility to 
      essential hypertension with or without T2DMin Malaysian subjects.
FAU - Ramachandran, Vasudevan
AU  - Ramachandran V
AD  - Genetic Research Group, Department of Biomedical Science, Faculty of Medicine and 
      Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia. vasuphd@gmail.com
FAU - Ismail, Patimah
AU  - Ismail P
FAU - Stanslas, Johnson
AU  - Stanslas J
FAU - Shamsudin, Norashikin
AU  - Shamsudin N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090225
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
RN  - 0 (Genetic Markers)
RN  - 11002-13-4 (Angiotensinogen)
RN  - EC 1.14.15.4 (Cytochrome P-450 CYP11B2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiotensinogen/*genetics
MH  - Cytochrome P-450 CYP11B2/genetics
MH  - Diabetes Mellitus, Type 2/diagnosis/epidemiology/*genetics
MH  - Female
MH  - Genetic Markers/genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Hypertension/diagnosis/epidemiology/*genetics
MH  - Malaysia/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Renin-Angiotensin System/*genetics
PMC - PMC2656464
EDAT- 2009/02/27 09:00
MHDA- 2009/12/16 06:00
PMCR- 2009/02/25
CRDT- 2009/02/27 09:00
PHST- 2008/10/29 00:00 [received]
PHST- 2009/02/25 00:00 [accepted]
PHST- 2009/02/27 09:00 [entrez]
PHST- 2009/02/27 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2009/02/25 00:00 [pmc-release]
AID - 1475-2840-8-11 [pii]
AID - 10.1186/1475-2840-8-11 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2009 Feb 25;8:11. doi: 10.1186/1475-2840-8-11.