PMID- 19245427
OWN - NLM
STAT- MEDLINE
DCOM- 20100106
LR  - 20151119
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 64
IP  - 9
DP  - 2009 Sep
TI  - Common variants in FCER1A influence total serum IgE levels from cord blood up to 
      six years of life.
PG  - 1327-32
LID - 10.1111/j.1398-9995.2009.02005.x [doi]
AB  - BACKGROUND: In a recent genome wide scan, a functional promoter variant 
      (rs2251746) in the gene encoding the alpha chain of the high affinity receptor 
      for immunoglobulin E (IgE) (FCER1A) was identified as major determinant of serum 
      IgE levels. OBJECTIVE: The aim of this study was to investigate the role of 
      rs2251746 on total IgE levels measured at different stages of life from birth 
      (cord blood) up to the age of 6 and to evaluate its interaction with the 
      environmental influences in two German birth cohorts. METHOD: Data from two 
      German birth cohorts were analysed (n = 1043 for the LISA cohort and n = 1842 for 
      the GINI cohort). In the studies, total serum IgE was measured from cord blood, 
      and blood samples taken at the age of 2/3 and 6 years. In a subgroup of the LISA 
      study, house dust samples were collected at age of 3 months and the amount of 
      endotoxin was determined. Random effect models were used to analyse the 
      longitudinal health outcomes. RESULTS: In the two cohorts, the heterozygote and 
      the rare homozygote of rs2251746 was consistently associated with lower total IgE 
      levels from birth up to the age of 6 years with an allele-dose effect (P < 0.02 
      for blood samples taken at each time point in both cohorts). No interaction 
      between the two FCER1A encoding gene and environmental exposures including 
      endotoxin, worm infestation and day care centre attendance during early childhood 
      were observed. CONCLUSION: Common variants in FCER1A strongly influence basal IgE 
      production independently from environmental stimuli. These effects can be 
      observed already in cord blood pointing to altered gene expression in foetus.
FAU - Chen, C-M
AU  - Chen CM
AD  - Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, 
      Institute of Epidemiology, Neuherberg, Germany.
FAU - Weidinger, S
AU  - Weidinger S
FAU - Klopp, N
AU  - Klopp N
FAU - Sausenthaler, S
AU  - Sausenthaler S
FAU - Bischof, W
AU  - Bischof W
FAU - Herbarth, O
AU  - Herbarth O
FAU - Bauer, M
AU  - Bauer M
FAU - Borte, M
AU  - Borte M
FAU - Schaaf, B
AU  - Schaaf B
FAU - Lehmann, I
AU  - Lehmann I
FAU - Behrendt, H
AU  - Behrendt H
FAU - Kramer, U
AU  - Kramer U
FAU - Berdel, D
AU  - Berdel D
FAU - von Berg, A
AU  - von Berg A
FAU - Bauer, C P
AU  - Bauer CP
FAU - Koletzko, S
AU  - Koletzko S
FAU - Illig, T
AU  - Illig T
FAU - Wichmann, H-E
AU  - Wichmann HE
FAU - Heinrich, J
AU  - Heinrich J
CN  - LISA and GINI Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090224
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Dust)
RN  - 0 (FCER1A protein, human)
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Allergy. 2009 Sep;64(9):1383. PMID: 19624557
MH  - Alleles
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Dust/immunology
MH  - Environmental Exposure
MH  - Fetal Blood/*immunology
MH  - Genotype
MH  - Heterozygote
MH  - Homozygote
MH  - Humans
MH  - Immunoglobulin E/*blood/genetics
MH  - Infant
MH  - Infant, Newborn
MH  - Longitudinal Studies
MH  - Polymorphism, Single Nucleotide/genetics/immunology
MH  - *Promoter Regions, Genetic
MH  - Receptors, IgE/*genetics/immunology
MH  - Surveys and Questionnaires
EDAT- 2009/02/28 09:00
MHDA- 2010/01/07 06:00
CRDT- 2009/02/28 09:00
PHST- 2009/02/28 09:00 [entrez]
PHST- 2009/02/28 09:00 [pubmed]
PHST- 2010/01/07 06:00 [medline]
AID - ALL2005 [pii]
AID - 10.1111/j.1398-9995.2009.02005.x [doi]
PST - ppublish
SO  - Allergy. 2009 Sep;64(9):1327-32. doi: 10.1111/j.1398-9995.2009.02005.x. Epub 2009 
      Feb 24.