PMID- 19245826
OWN - NLM
STAT- MEDLINE
DCOM- 20090616
LR  - 20101118
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 33
IP  - 3
DP  - 2009 Apr 30
TI  - Do schizophrenia and bipolar disorders share a common disease susceptibility 
      variant at the MMP3 gene?
PG  - 557-61
LID - 10.1016/j.pnpbp.2009.02.012 [doi]
AB  - There is growing evidence of partial etiological overlap between schizophrenia 
      (SZ) and bipolar I disorder (BD-I) from linkage analysis, genetic epidemiology 
      and molecular genetics studies. SZ and BD-I are neurodevelopmental disorders with 
      genetic and environmental etiologies. Recent studies have demonstrated that 
      matrix metalloproteinase 3 (MMP3) is a key event in associative memory formation, 
      learning and synaptic plasticity, which are important in psychiatric disorders. 
      In the light of these findings, we analyzed the genetic variations in the 
      MMP3-1171 5A/6A in patients with SZ, patients with BD-I and healthy controls. To 
      the best of our knowledge, this is the first study to report an association of 
      variation in gene encoding MMP3 with SZ. Our study group consisted of 111 
      unrelated patients with SZ, 141 unrelated patients with BD-I, and 121 unrelated 
      healthy controls. The frequencies of 6A6A genotype and 6A allele distributions of 
      MMP3 in patients with SZ were significantly decreased when compared with 
      controls. In contrast, in patients with SZ, the distributions of 5A5A genotype 
      and 5A allele of MMP3 gene were significantly increased as compared with healthy 
      controls. When the frequencies of genotypes or alleles in schizophrenic patients 
      and bipolar patients were compared, 6A6A genotype and 6A allele in patients with 
      BD-I were significantly higher than patients with SZ. In contrast, 5A5A genotype 
      and 5A allele distributions of MMP3 gene were significantly frequent in patients 
      with SZ. On the other hand, no significant differences were found in the allele 
      or genotype distribution in patients with BD-I compared with controls. In 
      conclusion, our data have supported the hypothesis that there is a possible 
      relationship between -1171 5A/6A polymorphism of MMP3 gene and SZ. A larger 
      sample group is needed to confirm the potential role of this gene in the 
      pathophysiology of psychiatric disorders.
FAU - Kucukali, Cem Ismail
AU  - Kucukali CI
AD  - Department of Neurology, Istanbul Erenkoy Psychiatric and Neurological Disorders 
      Hospital, Istanbul, Turkey.
FAU - Aydin, Makbule
AU  - Aydin M
FAU - Ozkok, Elif
AU  - Ozkok E
FAU - Bilge, Emine
AU  - Bilge E
FAU - Orhan, Nurcan
AU  - Orhan N
FAU - Zengin, Asli
AU  - Zengin A
FAU - Kara, Ihsan
AU  - Kara I
LA  - eng
PT  - Journal Article
DEP - 20090223
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/*genetics
MH  - Chi-Square Distribution
MH  - DNA Mutational Analysis
MH  - Female
MH  - Gene Frequency
MH  - Genetic Linkage
MH  - Genetic Predisposition to Disease/*genetics
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/*genetics
EDAT- 2009/02/28 09:00
MHDA- 2009/06/17 09:00
CRDT- 2009/02/28 09:00
PHST- 2008/10/02 00:00 [received]
PHST- 2009/02/13 00:00 [revised]
PHST- 2009/02/17 00:00 [accepted]
PHST- 2009/02/28 09:00 [entrez]
PHST- 2009/02/28 09:00 [pubmed]
PHST- 2009/06/17 09:00 [medline]
AID - S0278-5846(09)00052-9 [pii]
AID - 10.1016/j.pnpbp.2009.02.012 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30;33(3):557-61. doi: 
      10.1016/j.pnpbp.2009.02.012. Epub 2009 Feb 23.