PMID- 19247374
OWN - NLM
STAT- MEDLINE
DCOM- 20100203
LR  - 20221207
IS  - 1435-232X (Electronic)
IS  - 1434-5161 (Linking)
VI  - 54
IP  - 4
DP  - 2009 Apr
TI  - Complex divergence at a microsatellite marker C1_2_5 in the lineage of HLA-Cw/-B 
      haplotype.
PG  - 224-9
LID - 10.1038/jhg.2009.15 [doi]
AB  - The human leukocyte antigen (HLA) complex locus has shaped a framework for 
      evolutionary processes because of the dense clustering and strong linkage 
      disequilibrium (LD) of polymorphic genes. Although the landscape of LD among 
      conventional single-nucleotide polymorphisms (SNPs) has been described, the data 
      on the lineage of major histocompatibility complex (MHC) haplotype are limited to 
      pairwise comparisons of several haplotypes in Caucasoid populations. 
      Multi-allelic markers, including microsatellite markers, may provide us with a 
      larger power to analyze the MHC haplotype lineage because the mutation rate of 
      microsatellite exceeds that of SNPs by several orders of magnitude. In this 
      study, we investigated the complex structure of repeat motifs in a microsatellite 
      to figure out the structural lineage of HLA-Cw/-B segments in Japanese. It was 
      found that the genetic differences of HLA-Cw/-B haplotype lineage were reflected 
      by repeat motif patterns at C1_2_5 locus, suggesting that unique mutational 
      dynamics of microsatellites may be a useful marker to chase the haplotype 
      lineage.
FAU - Shichi, Daisuke
AU  - Shichi D
AD  - Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical 
      and Dental University, Tokyo, Japan.
FAU - Ota, Masao
AU  - Ota M
FAU - Katsuyama, Yoshihiko
AU  - Katsuyama Y
FAU - Inoko, Hidetoshi
AU  - Inoko H
FAU - Naruse, Taeko K
AU  - Naruse TK
FAU - Kimura, Akinori
AU  - Kimura A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090227
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - Genetic Loci
MH  - *Genetic Variation
MH  - HLA-B Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Japan
MH  - Linkage Disequilibrium/genetics
MH  - Microsatellite Repeats/*genetics
MH  - *Phylogeny
EDAT- 2009/02/28 09:00
MHDA- 2010/02/04 06:00
CRDT- 2009/02/28 09:00
PHST- 2009/02/28 09:00 [entrez]
PHST- 2009/02/28 09:00 [pubmed]
PHST- 2010/02/04 06:00 [medline]
AID - jhg200915 [pii]
AID - 10.1038/jhg.2009.15 [doi]
PST - ppublish
SO  - J Hum Genet. 2009 Apr;54(4):224-9. doi: 10.1038/jhg.2009.15. Epub 2009 Feb 27.