PMID- 19247701
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1555-8932 (Print)
IS  - 1865-3499 (Electronic)
IS  - 1555-8932 (Linking)
VI  - 4
IP  - 1
DP  - 2009 Mar
TI  - Chronic intracerebroventricular injection of TLQP-21 prevents high fat diet 
      induced weight gain in fast weight-gaining mice.
PG  - 49-57
LID - 10.1007/s12263-009-0110-0 [doi]
AB  - The vgf gene regulates energy homeostasis and the VGF-derived peptide TLQP-21 
      centrally exerts catabolic effects in mice and hamsters. Here, we investigate the 
      effect of chronic intracerebroventricular (icv) injection of TLQP-21 in mice fed 
      high fat diet (HFD). Fast weight-gaining mice injected with the peptide or 
      cerebrospinal fluid were selected for physiological, endocrine, and molecular 
      analysis. TLQP-21 selectively inhibited the increase in body weight and 
      epididymal white adipose tissue (eWAT) weight induced by HFD in control animals 
      despite both groups having a similar degree of hyperphagia. TLQP-21 normalized 
      the increase in leptin and decrease in ghrelin while increasing epinephrine and 
      epinephrine/norepinephrine ratio when compared to values in controls. Finally, 
      HFD-TLQP-21 mice showed a selective increase of eWAT beta3-adrenergic receptor 
      mRNA. Peroxisome-proliferator-activated-receptor-delta and hormone-sensing-lipase 
      mRNA were also upregulated. In conclusion, chronic icv infusion of TLQP-21 
      prevented the early phase of diet-induced obesity despite overfeeding. These 
      effects were paralleled by activation of catabolic pathways within the eWAT. Our 
      results further support a role for TLQP-21 as a catabolic neuropeptide.
FAU - Bartolomucci, Alessandro
AU  - Bartolomucci A
AD  - Institute of Neuroscience, CNR, Via del Fosso di Fiorano, 64/65, 00143, Rome, 
      Italy, alessandro.bartolomucci@unipr.it.
FAU - Bresciani, Elena
AU  - Bresciani E
FAU - Bulgarelli, Ilaria
AU  - Bulgarelli I
FAU - Rigamonti, Antonello E
AU  - Rigamonti AE
FAU - Pascucci, Tiziana
AU  - Pascucci T
FAU - Levi, Andrea
AU  - Levi A
FAU - Possenti, Roberta
AU  - Possenti R
FAU - Torsello, Antonio
AU  - Torsello A
FAU - Locatelli, Vittorio
AU  - Locatelli V
FAU - Muller, Eugenio E
AU  - Muller EE
FAU - Moles, Anna
AU  - Moles A
LA  - eng
PT  - Journal Article
DEP - 20090227
PL  - Germany
TA  - Genes Nutr
JT  - Genes & nutrition
JID - 101280108
PMC - PMC2654049
EDAT- 2009/02/28 09:00
MHDA- 2009/02/28 09:01
PMCR- 2009/03/01
CRDT- 2009/02/28 09:00
PHST- 2008/10/29 00:00 [received]
PHST- 2009/01/07 00:00 [accepted]
PHST- 2009/02/28 09:00 [entrez]
PHST- 2009/02/28 09:00 [pubmed]
PHST- 2009/02/28 09:01 [medline]
PHST- 2009/03/01 00:00 [pmc-release]
AID - 110 [pii]
AID - 10.1007/s12263-009-0110-0 [doi]
PST - ppublish
SO  - Genes Nutr. 2009 Mar;4(1):49-57. doi: 10.1007/s12263-009-0110-0. Epub 2009 Feb 
      27.