PMID- 19248814
OWN - NLM
STAT- MEDLINE
DCOM- 20090716
LR  - 20161125
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 47
IP  - 6
DP  - 2009 Jun
TI  - Mechanism of action of Rhodiola imbricata Edgew during exposure to cold, hypoxia 
      and restraint (C-H-R) stress induced hypothermia and post stress recovery in 
      rats.
PG  - 1239-45
LID - 10.1016/j.fct.2009.02.017 [doi]
AB  - Mechanism of rhodiola root extract adaptogenic activity was studied in rats. The 
      extract was orally administered in rats (100mg/kg body weight), 30 min prior to 
      cold (5 degrees C)-hypoxia (428 mmHg)-restraint (C-H-R) exposure up to fall of 
      T(rec)23 degrees C and recovery (T(rec)37 degrees C) from hypothermia. In 
      untreated control rats serum lactate and non-esterified fatty acids (NEFA) 
      increased on attaining T(rec)23 degrees C with decreased blood enzyme activities 
      hexokinase (HK), phosphofructokinase (PFK), citrate synthase (CS) and 
      glucose-6-phosphate dehydrogenase (G-6-PD), on attaining T(rec)23 degrees C and 
      T(rec)37 degrees C. Decreases were also observed in liver and muscle tissues HK 
      and G-6-PD enzyme activities and liver glycogen and CS on attaining T(rec)23 
      degrees C and recovery; muscle PFK during recovery; muscle CS on attaining 
      T(rec)23 degrees C. Single and five doses of extract administration restricted 
      increase in serum lactate values of rats on attaining T(rec)23 degrees C and 
      maintained blood NEFA in single dose extract treated animals, indicating improved 
      utilization of NEFA as energy fuel. The single and five doses extract treatment 
      decreased or better maintained tissue glycogen and enzyme activities, viz. HK, 
      PFK, CS and G-6-PD, in blood, liver and muscle, on attaining T(rec)23 degrees C 
      and recovery. The results suggest that rhodiola extract treatment in rats shifted 
      anaerobic metabolism to aerobic, during C-H-R exposure and post stress recovery.
FAU - Gupta, Vanita
AU  - Gupta V
AD  - Department of Biochemical Pharmacology, Defence Institute of Physiology and 
      Allied Sciences (DIPAS), Lucknow Road, Timarpur, Delhi 110 054, India. 
      vanitagupta06@yahoo.co.in
FAU - Lahiri, S S
AU  - Lahiri SS
FAU - Sultana, S
AU  - Sultana S
FAU - Kumar, Ratan
AU  - Kumar R
LA  - eng
PT  - Journal Article
DEP - 20090225
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Plant Extracts)
RN  - 0 (Proteins)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 9005-79-2 (Glycogen)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Cold Temperature/*adverse effects
MH  - Energy Metabolism/drug effects
MH  - Fatty Acids, Nonesterified/metabolism
MH  - Glycogen/metabolism
MH  - Glycolysis/drug effects
MH  - Hypothermia/*etiology/physiopathology
MH  - Hypoxia/*prevention & control
MH  - Lactic Acid/metabolism
MH  - Male
MH  - Plant Extracts/pharmacology
MH  - Plant Roots/chemistry
MH  - Proteins/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Restraint, Physical
MH  - Rhodiola/*chemistry
MH  - Stress, Psychological/*drug therapy/psychology
EDAT- 2009/03/03 09:00
MHDA- 2009/07/17 09:00
CRDT- 2009/03/03 09:00
PHST- 2008/11/07 00:00 [received]
PHST- 2009/02/09 00:00 [revised]
PHST- 2009/02/16 00:00 [accepted]
PHST- 2009/03/03 09:00 [entrez]
PHST- 2009/03/03 09:00 [pubmed]
PHST- 2009/07/17 09:00 [medline]
AID - S0278-6915(09)00094-5 [pii]
AID - 10.1016/j.fct.2009.02.017 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2009 Jun;47(6):1239-45. doi: 10.1016/j.fct.2009.02.017. Epub 
      2009 Feb 25.