PMID- 19248822
OWN - NLM
STAT- MEDLINE
DCOM- 20091021
LR  - 20090414
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 160
IP  - 2
DP  - 2009 May 5
TI  - Transforming growth factor-alpha induces neurogenesis and behavioral improvement 
      in a chronic stroke model.
PG  - 470-83
LID - 10.1016/j.neuroscience.2009.02.029 [doi]
AB  - Transforming growth factor-alpha (TGFalpha) is a powerful endogenous mitogen and 
      neurotrophic factor, which has previously been shown to induce a massive 
      proliferative response in the brains of Parkinson's disease model rats injured by 
      an acute neurotoxic lesion. We now show that TGFalpha can also produce a massive 
      proliferative response in rat brains subjected to stroke caused by a middle 
      cerebral artery occlusion (MCAO), even when the growth factor is administered as 
      late as 4 weeks after injury. This combination of stimuli provokes DNA synthesis, 
      shown by 5'-bromo-2-deoxyuridine incorporation, throughout the ependymal layer 
      and subventricular zone (SVZ) of the forebrain during the 4 weeks of growth 
      factor administration. The newly generated cells migrate preferentially along and 
      ventral to the corpus callosum (CC) and external capsule to the site of the 
      injury where many of them differentiate into several site-appropriate neuronal 
      phenotypes in association with near complete (99%) behavioral recovery. We 
      conclude that the injury response of endogenous neural stem cells as well as 
      behavioral recovery can be significantly enhanced by application of TGFalpha, and 
      that this approach represents a potential therapeutic strategy for chronic stroke 
      and other neurological damage in human patients.
FAU - Guerra-Crespo, M
AU  - Guerra-Crespo M
AD  - Department of Anatomy and Neurobiology, University of California, Irvine, 335 
      Medical Surgery II, Irvine, CA 92697, USA. magdagmx@hotmail.com
FAU - Gleason, D
AU  - Gleason D
FAU - Sistos, A
AU  - Sistos A
FAU - Toosky, T
AU  - Toosky T
FAU - Solaroglu, I
AU  - Solaroglu I
FAU - Zhang, J H
AU  - Zhang JH
FAU - Bryant, P J
AU  - Bryant PJ
FAU - Fallon, J H
AU  - Fallon JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090225
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Transforming Growth Factor alpha)
SB  - IM
MH  - Adult Stem Cells/cytology/drug effects/*physiology
MH  - Analysis of Variance
MH  - Animals
MH  - Cell Differentiation/drug effects/physiology
MH  - Cell Movement/drug effects/physiology
MH  - Cell Proliferation/drug effects
MH  - Chronic Disease
MH  - Disease Models, Animal
MH  - Motor Activity/physiology
MH  - Neostriatum/cytology/pathology/physiology
MH  - Neurogenesis/drug effects/*physiology
MH  - Neurons/drug effects/pathology/*physiology
MH  - Rats
MH  - Recovery of Function/physiology
MH  - Spatial Behavior/physiology
MH  - Statistics, Nonparametric
MH  - Stroke/*pathology/physiopathology
MH  - Time Factors
MH  - Transforming Growth Factor alpha/administration & dosage/*physiology
EDAT- 2009/03/03 09:00
MHDA- 2009/10/22 06:00
CRDT- 2009/03/03 09:00
PHST- 2008/11/06 00:00 [received]
PHST- 2009/01/26 00:00 [revised]
PHST- 2009/02/04 00:00 [accepted]
PHST- 2009/03/03 09:00 [entrez]
PHST- 2009/03/03 09:00 [pubmed]
PHST- 2009/10/22 06:00 [medline]
AID - S0306-4522(09)00189-4 [pii]
AID - 10.1016/j.neuroscience.2009.02.029 [doi]
PST - ppublish
SO  - Neuroscience. 2009 May 5;160(2):470-83. doi: 10.1016/j.neuroscience.2009.02.029. 
      Epub 2009 Feb 25.