PMID- 19250079
OWN - NLM
STAT- MEDLINE
DCOM- 20090529
LR  - 20090302
IS  - 1540-8159 (Electronic)
IS  - 0147-8389 (Linking)
VI  - 32 Suppl 1
DP  - 2009 Mar
TI  - Long-term outcomes of CRT-PM versus CRT-D recipients.
PG  - S141-5
LID - 10.1111/j.1540-8159.2008.02271.x [doi]
AB  - OBJECTIVE: To compare the rates of all-cause mortality in recipients of cardiac 
      resynchronization therapy devices without (CRT-PM) versus with defibrillator 
      (CRT-D). METHODS: Between February 1999 and July 2004, 233 patients (mean age = 
      69 +/- 8 years, 180 men) underwent implantation of CRT-PM or CRT-D devices. New 
      York Heart Association (NYHA) heart failure functional class II was present in 
      11%, class III in 69%, and class IV in 20% of patients; mean left ventricle 
      ejection fraction (LVEF) was 26.5 +/- 6.5 %, 48% presented with idiopathic 
      dilated cardiomyopathy and 49% with ischemic heart disease. Cox multiple variable 
      regression analysis was performed in search of predictors of death. RESULTS: The 
      clinical characteristics of the 117 CRT-PM and 116 CRT-D recipients were similar, 
      except for LVEF (28.2 +/- 6.2% vs 25.0 +/- 6.5%, respectively; P < 0.001), and 
      ischemic versus nonischemic etiology of heart failure (41% vs 56%, respectively P 
      = 0.02). Over a mean follow-up of 58 +/- 15 months, no significance difference in 
      overall mortality rate was observed between the two study groups. Male sex, NYHA 
      functional class IV, and atrial fibrillation at implant were significant 
      predictors of death. CONCLUSIONS: There was no difference in long-term survival 
      rate among patients with CRT-D versus CRT-PM, although CRT-D more effectively 
      lowered the sudden death rate. Male sex, NYHA functional class IV, and atrial 
      fibrillation predicted the worst prognosis.
FAU - Stabile, Giuseppe
AU  - Stabile G
AD  - Clinica Mediterranea, Napoli, Italy. gmrstabile@tin.it
FAU - Solimene, Francesco
AU  - Solimene F
FAU - Bertaglia, Emanuele
AU  - Bertaglia E
FAU - La Rocca, Vincenzo
AU  - La Rocca V
FAU - Accogli, Michele
AU  - Accogli M
FAU - Scaccia, Alberto
AU  - Scaccia A
FAU - Marrazzo, Natale
AU  - Marrazzo N
FAU - Zoppo, Franco
AU  - Zoppo F
FAU - Turco, Pietro
AU  - Turco P
FAU - Iuliano, Assunta
AU  - Iuliano A
FAU - Shopova, Gergana
AU  - Shopova G
FAU - Ciardiello, Carmine
AU  - Ciardiello C
FAU - De Simone, Antonio
AU  - De Simone A
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - Aged
MH  - Cardiac Pacing, Artificial/*mortality
MH  - Death, Sudden, Cardiac/*epidemiology/*prevention & control
MH  - Female
MH  - Heart Failure/*epidemiology/*prevention & control
MH  - Humans
MH  - Italy/epidemiology
MH  - Longitudinal Studies
MH  - Male
MH  - Pacemaker, Artificial/*statistics & numerical data
MH  - Prevalence
MH  - Risk Assessment/*methods
MH  - Risk Factors
MH  - *Survival Analysis
MH  - Treatment Outcome
EDAT- 2009/03/11 09:00
MHDA- 2009/05/30 09:00
CRDT- 2009/03/03 09:00
PHST- 2009/03/03 09:00 [entrez]
PHST- 2009/03/11 09:00 [pubmed]
PHST- 2009/05/30 09:00 [medline]
AID - PACE2271 [pii]
AID - 10.1111/j.1540-8159.2008.02271.x [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2009 Mar;32 Suppl 1:S141-5. doi: 
      10.1111/j.1540-8159.2008.02271.x.