PMID- 19250080
OWN - NLM
STAT- MEDLINE
DCOM- 20090529
LR  - 20090302
IS  - 1540-8159 (Electronic)
IS  - 0147-8389 (Linking)
VI  - 32 Suppl 1
DP  - 2009 Mar
TI  - Diabetes does not affect ventricular repolarization and sudden cardiac death risk 
      in patients with dilated cardiomyopathy.
PG  - S146-50
LID - 10.1111/j.1540-8159.2008.02272.x [doi]
AB  - BACKGROUND: We studied the effects of diabetes on ventricular repolarization 
      parameters and sudden cardiac death in patients with dilated cardiomyopathy 
      (DCM). METHODS: We enrolled 132 consecutive patients in New York Heart 
      Association (NYHA) heart failure functional classes II or III and left 
      ventricular ejection fraction <40% without evidence of coronary artery disease. 
      In 45 patients (34%), diabetes was diagnosed according to standard criteria 
      (study group), and the remaining 87 (66%) had no diabetes (controls). All 
      patients underwent a 5-minute high-resolution electrocardiogram recording for 
      determination of QT variability (QTV) index and were followed for 1 year 
      thereafter. RESULTS: At baseline, the two groups did not differ in age, gender, 
      left ventricular ejection fraction, NYHA functional class, or plasma brain 
      natriuretic peptide levels. Similarly, QTV index did not differ between the study 
      group (-0.51 +/- 0.55) and controls (-0.48 +/- 0.51; P = 0.48). During follow-up, 
      18 patients (14%) died of cardiac causes. Of the 18 deaths, eight were attributed 
      to heart failure, and 10 to sudden cardiac death. Mortality was higher in the 
      study group (10/45, 20%) than in controls (8/87, 10%) (P = 0.03). The same was 
      true of the heart failure mortality (6/45 [13%] vs 2/87 [2%], P = 0.01), but not 
      of the sudden cardiac death rate (3/45 [7%] vs 7/87 [8%], P = 0.78). By multiple 
      variable analyses, diabetes predicted total and heart failure mortality, and a 
      high QTV predicted sudden cardiac death. CONCLUSIONS: Diabetes appears to 
      increase the risk of heart failure in patients with DCM without affecting 
      ventricular repolarization parameters and sudden cardiac death risk.
FAU - Vrtovec, Bojan
AU  - Vrtovec B
AD  - Advanced Heart Failure Center, Department of Cardiology, Ljubljana University 
      Medical Center, Ljubljana, Slovenia. gmrstabile@tin.it
FAU - Fister, Misa
AU  - Fister M
FAU - Poglajen, Gregor
AU  - Poglajen G
FAU - Starc, Vito
AU  - Starc V
FAU - Haddad, Francois
AU  - Haddad F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - Cardiomyopathy, Dilated/diagnosis/*mortality/*prevention & control
MH  - Comorbidity
MH  - Death, Sudden, Cardiac/*epidemiology/*prevention & control
MH  - Diabetes Mellitus/*mortality
MH  - Electrocardiography/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Assessment
MH  - Slovenia/epidemiology
MH  - Survival Analysis
MH  - Survival Rate
EDAT- 2009/03/11 09:00
MHDA- 2009/05/30 09:00
CRDT- 2009/03/03 09:00
PHST- 2009/03/03 09:00 [entrez]
PHST- 2009/03/11 09:00 [pubmed]
PHST- 2009/05/30 09:00 [medline]
AID - PACE2272 [pii]
AID - 10.1111/j.1540-8159.2008.02272.x [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2009 Mar;32 Suppl 1:S146-50. doi: 
      10.1111/j.1540-8159.2008.02272.x.