PMID- 19250325
OWN - NLM
STAT- MEDLINE
DCOM- 20090901
LR  - 20171116
IS  - 1468-3083 (Electronic)
IS  - 0926-9959 (Linking)
VI  - 23
IP  - 6
DP  - 2009 Jun
TI  - B7-2/CD28 costimulatory pathway in children with atopic dermatitis and its 
      connection with immunoglobulin E, intracellular interleukin-4 and 
      interferon-gamma production by T cells during a 1-month follow-up.
PG  - 656-9
LID - 10.1111/j.1468-3083.2009.03133.x [doi]
AB  - BACKGROUND: The best defined costimulators for activation of T lymphocytes are 
      B7-1 and B7-2 on antigen presenting cells (APC) that bind to CD28 on T cells. 
      Several studies showed that CD28 is critical for type 2 T helper cells (Th2) 
      inflammation and depends mainly on the interaction of CD28 with B7-2. Some 
      authors suggested a role for B7-2 B cells in immunoglobulin E (IgE) synthesis. 
      OBJECTIVE: We decided to study B7-2/CD28 interaction in atopic dermatitis (AD) 
      and correlations with total and specific IgE, intracellular interleukin 4-(IL-4) 
      and interferon-gamma (IFN-gamma) production during a 1-month follow-up. METHODS: 
      We studied 24 AD children with allergy to cow's milk. Lymphocyte subsets (B7-2 on 
      B cells, CD28(+) on T cells, IL-4 and IFN-gamma producing T helper cells), total 
      and specific IgE, and IgG4 at days 1 and 30 were also studied. Scoring of atopic 
      dermatitis (SCORAD) significantly decreased. RESULTS: CD28(+)/CD3(+)/CD57 
      correlated with B7-2 B cells at days 1 and 30, with IL-4 and IFN-gamma producing 
      T helper cells at day 1 and with SCORAD at day 30. B7-2 B cells negatively 
      correlated with IgE at day 30. Percentage of B7-2 B cells negatively correlated 
      with total and specific IgE at day 30. CONCLUSION: Our results support the 
      importance of CD28/B7 costimulation in AD children and the relation of CD28 with 
      Th1 and Th2 cytokines. However, our results do not confirm the hypothesis about 
      the preferential role of B7-2 in Th2 activation and IgE synthesis. It could raise 
      a question about B7-2 blockade efficacy in AD children. Further investigations on 
      B7 family members and their functions could help to distinguish target for more 
      clinically efficient B7/CD28 blockage in AD.
FAU - Chernyshov, P V
AU  - Chernyshov PV
AD  - Department of Dermatology and Venereology, National Medical University, Kiev, 
      Ukraine. chernyshovpavel@ukr.net
LA  - eng
PT  - Journal Article
DEP - 20090224
PL  - England
TA  - J Eur Acad Dermatol Venereol
JT  - Journal of the European Academy of Dermatology and Venereology : JEADV
JID - 9216037
RN  - 0 (B7-1 Antigen)
RN  - 0 (CD28 Antigens)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - B7-1 Antigen/*immunology
MH  - CD28 Antigens/*immunology
MH  - Child, Preschool
MH  - Dermatitis, Atopic/*immunology
MH  - Flow Cytometry
MH  - Humans
MH  - Immunoglobulin E/*biosynthesis
MH  - Infant
MH  - Interferon-gamma/*biosynthesis
MH  - Interleukin-4/*biosynthesis
MH  - Lymphocyte Subsets
MH  - T-Lymphocytes/immunology/*metabolism
EDAT- 2009/03/03 09:00
MHDA- 2009/09/02 06:00
CRDT- 2009/03/03 09:00
PHST- 2009/03/03 09:00 [entrez]
PHST- 2009/03/03 09:00 [pubmed]
PHST- 2009/09/02 06:00 [medline]
AID - JDV3133 [pii]
AID - 10.1111/j.1468-3083.2009.03133.x [doi]
PST - ppublish
SO  - J Eur Acad Dermatol Venereol. 2009 Jun;23(6):656-9. doi: 
      10.1111/j.1468-3083.2009.03133.x. Epub 2009 Feb 24.