PMID- 19251259
OWN - NLM
STAT- MEDLINE
DCOM- 20090825
LR  - 20090622
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 205
IP  - 1
DP  - 2009 Jul
TI  - C-reactive protein predicts functional status and correlates with left 
      ventricular ejection fraction in patients with chronic stable angina.
PG  - 319-24
LID - 10.1016/j.atherosclerosis.2008.12.018 [doi]
AB  - C-reactive protein (CRP) is a marker for cardiovascular risk but may also 
      participate in the pathogenesis of atherosclerosis and myocardial injury. We 
      sought to investigate the relationship among CRP, left ventricular ejection 
      fraction (LVEF) and symptoms of congestive heart failure (CHF) in patients with 
      chronic stable angina (CSA) pectoris. METHODS: We studied 841 patients (63+/-10 
      years, 72% men) with CSA undergoing coronary angiography. Symptoms of CHF were 
      assessed using the New York Heart Association (NYHA) functional classification. 
      CRP measurements were performed using a high sensitivity (hs-) immunoassay at the 
      time of diagnostic coronary angiography. RESULTS: Baseline serum hs-CRP levels 
      showed a significant correlation with LVEF (r=-0.11; P=0.004), and prevalence of 
      moderate-to-severe CHF correlated with serum hs-CRP quartiles (P(trend)<0.0001). 
      After adjustment, age (P=0.004), female gender (P=0.03), body mass index 
      (P<0.0001) and hs-CRP (OR 2.2 [1.3-3.6] CI 95%; P=0.002) were independent 
      predictors of NYHA functional classes III-IV irrespective of LVEF and 
      angiographic severity of CAD. A CRP value of 3.2mg/L had a sensitivity of 72%, a 
      specificity of 75%, and a negative predictive value of 96% for detecting an 
      impaired functional class. INTERPRETATION: Hs-CRP serum concentrations showed an 
      inverse correlation with LVEF and were an independent predictor of NYHA 
      functional class in patients with CSA.
FAU - Arroyo-Espliguero, Ramon
AU  - Arroyo-Espliguero R
AD  - Division of Cardiology, Hospital General Universitario, Guadalajara, Spain.
FAU - Avanzas, Pablo
AU  - Avanzas P
FAU - Quiles, Juan
AU  - Quiles J
FAU - Kaski, Juan Carlos
AU  - Kaski JC
LA  - eng
PT  - Journal Article
DEP - 20081214
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Angina Pectoris/*blood
MH  - C-Reactive Protein/*biosynthesis
MH  - Cardiovascular Diseases/blood/diagnosis
MH  - Chronic Disease
MH  - Coronary Angiography/methods
MH  - Female
MH  - Heart Failure/blood/diagnosis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Ventricular Dysfunction, Left/*blood
MH  - Ventricular Function, Left/physiology
EDAT- 2009/03/03 09:00
MHDA- 2009/08/26 09:00
CRDT- 2009/03/03 09:00
PHST- 2008/03/13 00:00 [received]
PHST- 2008/12/03 00:00 [revised]
PHST- 2008/12/08 00:00 [accepted]
PHST- 2009/03/03 09:00 [entrez]
PHST- 2009/03/03 09:00 [pubmed]
PHST- 2009/08/26 09:00 [medline]
AID - S0021-9150(08)00890-3 [pii]
AID - 10.1016/j.atherosclerosis.2008.12.018 [doi]
PST - ppublish
SO  - Atherosclerosis. 2009 Jul;205(1):319-24. doi: 
      10.1016/j.atherosclerosis.2008.12.018. Epub 2008 Dec 14.