PMID- 19252293
OWN - NLM
STAT- MEDLINE
DCOM- 20090428
LR  - 20190720
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 32
IP  - 3
DP  - 2009 Mar
TI  - A novel (S)-(+)-decursin derivative, (S)-(+)-3-(3,4-dihydroxy-phenyl)-acrylic 
      acid 2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano[3,2-g]chromen-3-yl-ester, 
      inhibits ovalbumin-induced lung inflammation in a mouse model of asthma.
PG  - 444-9
AB  - (S)-(+)-Decursin is a coumarin compound present in herbal extracts that has 
      various biological activities. (S)-(+)-Decursin attenuates pathophysiologic 
      progression in cancer, bacterial infection and neuropathy. Asthma is an 
      inflammatory disease associated with increased infiltration of leukocytes, 
      especially eosinophils, and secretion of mucus into the airways. Although 
      (S)-(+)-decursin, as well as (S)-(+)-decursin analogues, have various 
      pharmacological properties, the effect of these compounds on asthma is not known. 
      In the present study, we synthesized (S)-(+)-3-(3,4-dihydroxy-phenyl)-acrylic 
      acid 2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano[3,2-g]chromen-3-yl-ester 
      (compound 6, C6) from (S)-(+)-decursin and examined if C6 had any inhibitory 
      effects on lung inflammation in a mouse model of ovalbumin-induced asthma. C6 
      significantly inhibited the leukocytosis (p < 0.01) and eosinophilia (p < 0.05) 
      in bronchoalveolar lavage (BAL) fluid. Examination of lung tissues stained with 
      hematoxylin and eosin and periodic acid Schiff reagents showed that C6 suppressed 
      the increased infiltration of inflammatory cells and elevated mucus 
      hypersecretion. Protein levels of interleukin (IL)-5 (p < 0.05) and eotaxin (p < 
      0.01) were significantly reduced in BAL fluid by C6. C6 also significantly 
      reduced total and ovalbumin-specific immunoglobulin E (IgE) levels in BAL fluid 
      (p < 0.01) as well as that in serum (p < 0.05). C6 may have pharmacological 
      effects for asthma and may be a potent therapeutic agent for the treatment of 
      allergic airway diseases.
FAU - Yang, Eun Ju
AU  - Yang EJ
AD  - Department of Biomedical Laboratory Science, School of Medicine, Eulji 
      University, Daejeon, Republic of Korea.
FAU - Song, Gyu-Yong
AU  - Song GY
FAU - Lee, Ji-Sook
AU  - Lee JS
FAU - Yun, Chi-Young
AU  - Yun CY
FAU - Kim, In Sik
AU  - Kim IS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (3-(3,4-dihydroxy-phenyl)-acrylic acid 
      2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano(3,2-g)chromen-3-yl-ester)
RN  - 0 (Acrylates)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Benzopyrans)
RN  - 0 (Butyrates)
RN  - 0 (Chromans)
RN  - 0 (Cytokines)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
RN  - E95RTO3YQR (decursin)
SB  - IM
MH  - Acrylates/*chemical synthesis/chemistry/pharmacology
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*chemical 
      synthesis/chemistry/pharmacology
MH  - Asthma/*drug therapy/immunology/pathology
MH  - Benzopyrans/chemistry
MH  - Butyrates/chemistry
MH  - Chromans/*chemical synthesis/chemistry/pharmacology
MH  - Cytokines/biosynthesis
MH  - Immunoglobulin E/biosynthesis
MH  - Leukocytes/immunology
MH  - Lung/*drug effects/immunology/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mucus/metabolism
MH  - Ovalbumin/*immunology
MH  - Pneumonia/drug therapy/immunology/pathology
MH  - Stereoisomerism
MH  - Th2 Cells/metabolism
EDAT- 2009/03/03 09:00
MHDA- 2009/04/29 09:00
CRDT- 2009/03/03 09:00
PHST- 2009/03/03 09:00 [entrez]
PHST- 2009/03/03 09:00 [pubmed]
PHST- 2009/04/29 09:00 [medline]
AID - JST.JSTAGE/bpb/32.444 [pii]
AID - 10.1248/bpb.32.444 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2009 Mar;32(3):444-9. doi: 10.1248/bpb.32.444.