PMID- 19252356
OWN - NLM
STAT- MEDLINE
DCOM- 20090603
LR  - 20190606
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 48
IP  - 5
DP  - 2009
TI  - Primitive neuroectodermal tumor of the pancreas.
PG  - 329-33
AB  - The primitive neuroectodermal tumor (PNET) of the pancreas, a member of Ewing's 
      sarcoma family of tumors, is extremely rare. We treated a 37-year-old Japanese 
      man who had a solitary pancreatic tumor 40 mm in diameter and multiple hepatic 
      tumors with surgical resection. The PNET was positive for CD99 on 
      immunohistochemical staining. Fluorescence in situ hybridization (FISH) was also 
      performed, which revealed a Ewing sarcoma breakpoint region 1 (EWSR1) 22q12 
      rearrangement. According to the Japan-Ewing protocol, chemotherapy with Ifomide 
      (ifosfamide), etoposide, vincristine, and cyclophosphamide was given after 
      surgery. To the best of our knowledge, to date 13 PNET cases have been reported 
      with a mean age for all patients of 19.3 years old. Surgical resection was 
      performed in most cases and some patients received postoperative chemotherapy. 
      The clinicopathologic characteristics and management of this extremely rare 
      disease are also discussed.
FAU - Doi, Hirokazu
AU  - Doi H
AD  - Department of Gastroenterology, Ehime Prefectural Central Hospital, Matsuyama.
FAU - Ichikawa, Soichi
AU  - Ichikawa S
FAU - Hiraoka, Atsushi
AU  - Hiraoka A
FAU - Ichiryu, Misa
AU  - Ichiryu M
FAU - Nakahara, Hiromasa
AU  - Nakahara H
FAU - Ochi, Hironori
AU  - Ochi H
FAU - Tanabe, Atsushi
AU  - Tanabe A
FAU - Kodama, Akihiro
AU  - Kodama A
FAU - Hasebe, Aki
AU  - Hasebe A
FAU - Miyamoto, Yasunao
AU  - Miyamoto Y
FAU - Ninomiya, Tomoyuki
AU  - Ninomiya T
FAU - Horiike, Norio
AU  - Horiike N
FAU - Takamura, Kazuhito
AU  - Takamura K
FAU - Kawasaki, Hideki
AU  - Kawasaki H
FAU - Kameoka, Chieko
AU  - Kameoka C
FAU - Kan, Miki
AU  - Kan M
FAU - Doi, Shigekazu
AU  - Doi S
FAU - Soga, Yoshiko
AU  - Soga Y
FAU - Tamura, Hiromi
AU  - Tamura H
FAU - Maeda, Toshiharu
AU  - Maeda T
FAU - Asaki, Akinori
AU  - Asaki A
FAU - Seno, Seijin
AU  - Seno S
FAU - Iguchi, Haruo
AU  - Iguchi H
FAU - Hasegawa, Tadashi
AU  - Hasegawa T
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20090302
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Calmodulin-Binding Proteins)
RN  - 0 (EWSR1 protein, human)
RN  - 0 (RNA-Binding Protein EWS)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Adult
MH  - Calmodulin-Binding Proteins/genetics
MH  - Drug Therapy
MH  - Humans
MH  - Male
MH  - Neuroectodermal Tumors, Primitive/*diagnosis/drug therapy/surgery
MH  - Pancreatic Neoplasms/*diagnosis/drug therapy/surgery
MH  - Positron-Emission Tomography
MH  - RNA-Binding Protein EWS
MH  - RNA-Binding Proteins/genetics
EDAT- 2009/03/03 09:00
MHDA- 2009/06/06 09:00
CRDT- 2009/03/03 09:00
PHST- 2009/03/03 09:00 [entrez]
PHST- 2009/03/03 09:00 [pubmed]
PHST- 2009/06/06 09:00 [medline]
AID - JST.JSTAGE/internalmedicine/48.1484 [pii]
AID - 10.2169/internalmedicine.48.1484 [doi]
PST - ppublish
SO  - Intern Med. 2009;48(5):329-33. doi: 10.2169/internalmedicine.48.1484. Epub 2009 
      Mar 2.