PMID- 19253027
OWN - NLM
STAT- MEDLINE
DCOM- 20100310
LR  - 20211020
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 37
IP  - 1
DP  - 2010 Jan
TI  - Interleukin-7 receptor-alpha gene polymorphisms in bone marrow transplant 
      recipients.
PG  - 27-31
LID - 10.1007/s11033-009-9488-4 [doi]
AB  - Graft-versus-host disease is the main complication after hematopoietic stem cells 
      transplantation (HSCT). Non-HLA genotypes, such as cytokines, have been 
      investigated for their potential roles in the occurrence and severity of GVHD as 
      well as for their contribution to overall transplant-related mortality and 
      survival. IL-7 which is secreted by bone marrow stromal cells plays an important 
      role in the development and survival of T cells. Its effect is mediated via 
      interleukin 7 receptor (IL7R). This study investigates the possible links between 
      IL-7alphaR single nucleotide polymorphisms (+510 C/T, +1237 A/G, +2087 T/C and 
      +3110A/G) and transplant outcomes among 116 recipients of HSCT. Genotypes were 
      determined using polymerase chain reaction-sequence-specific primers. No 
      significant differences were observed between the genotypic distributions of 
      IL-7alphaR polymorphisms and incidence of acute or chronic graft versus host 
      disease. Additional studies with larger sample are necessary to further define 
      the influence of IL-7alphaR on the immune response after bone marrow 
      transplantation.
FAU - Azarpira, Negar
AU  - Azarpira N
AD  - Organ Transplant Research Center, Shiraz University of Medical Sciences, Zand 
      Street, Nemazi Hospital, Shiraz, Iran. negarazarpira@yahoo.com
FAU - Dehghani, Mehdi
AU  - Dehghani M
FAU - Aghdaie, Mahdokth H
AU  - Aghdaie MH
FAU - Darai, Masumeh
AU  - Darai M
LA  - eng
PT  - Journal Article
DEP - 20090301
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Interleukin-7 Receptor alpha Subunit)
SB  - IM
MH  - Adult
MH  - *Bone Marrow Transplantation
MH  - Demography
MH  - Female
MH  - Genotype
MH  - Graft vs Host Disease/genetics
MH  - Humans
MH  - Interleukin-7 Receptor alpha Subunit/*genetics
MH  - Male
MH  - Polymorphism, Single Nucleotide/*genetics
EDAT- 2009/03/03 09:00
MHDA- 2010/03/11 06:00
CRDT- 2009/03/03 09:00
PHST- 2008/11/25 00:00 [received]
PHST- 2009/02/19 00:00 [accepted]
PHST- 2009/03/03 09:00 [entrez]
PHST- 2009/03/03 09:00 [pubmed]
PHST- 2010/03/11 06:00 [medline]
AID - 10.1007/s11033-009-9488-4 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2010 Jan;37(1):27-31. doi: 10.1007/s11033-009-9488-4. Epub 2009 Mar 
      1.