PMID- 19253553
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20161124
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 26
IP  - 6
DP  - 2008 Nov
TI  - [Determination of ginkgolic acids in Ginkgo biloba leaves by gas chromatography 
      with on-line pyrolytic methylation].
PG  - 731-5
AB  - A method to determine ginkgolic acids in Ginkgo biloba leaves was developed on 
      the basis of pyrolytic methylation-gas chromatography. Pyrolytic methylation of 
      G. biloba leaves in the injector at 300 degrees C in the presence of an organic 
      alkali, tetramethylammonium hydroxide (TMAH, 25% methanol), allowed quantitative 
      analysis of ginkgolic acids as their corresponding methyl derivatives. On the 
      basis of the relative areas of these peaks, chemical composition of the ginkgolic 
      acids in G. biloba leaves was determined with the relative standard deviations 
      (RSDs) less than 3.4% (n = 3). The calibration curves of 5 main ginkgolic acids 
      showed good linearity with the correlation coefficients greater than 0.996 6. The 
      detection limits were between 0.8 - 2.8 mg/kg for the 5 compounds (S/N = 3). It 
      is a simple, accurate and highly sensitive method for the chemical analysis and 
      quality control of ginkgolic acids in G. biloba leaves and extracts.
FAU - Wang, Lili
AU  - Wang L
AD  - College of Chemical Engineering and Materials Science, Zhejiang University of 
      Technology, Hangzhou 310014, China. lili_wang@zjut.edu.cn
FAU - Jia, Yilu
AU  - Jia Y
FAU - Pan, Zaifa
AU  - Pan Z
FAU - Xu, Hongxing
AU  - Xu H
FAU - Zheng, Xusong
AU  - Zheng X
FAU - Lu, Zhongxian
AU  - Lu Z
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Quaternary Ammonium Compounds)
RN  - 0 (Salicylates)
RN  - 22910-60-7 (ginkgolic acid)
RN  - H0W55235FC (tetramethylammonium)
SB  - IM
MH  - Calibration
MH  - Chromatography, Gas/*methods
MH  - Ginkgo biloba/*chemistry
MH  - *Hot Temperature
MH  - Methylation
MH  - Plant Leaves/*chemistry
MH  - Quaternary Ammonium Compounds/chemistry
MH  - Salicylates/*analysis/*chemistry
EDAT- 2009/03/04 09:00
MHDA- 2010/06/18 06:00
CRDT- 2009/03/04 09:00
PHST- 2009/03/04 09:00 [entrez]
PHST- 2009/03/04 09:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
PST - ppublish
SO  - Se Pu. 2008 Nov;26(6):731-5.