PMID- 19253840
OWN - NLM
STAT- MEDLINE
DCOM- 20100302
LR  - 20231213
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 39
IP  - 6
DP  - 2008 Nov
TI  - [The expression of human leukocyte antigen G and E on human first trimester 
      placenta and its relationship with recurrent spontaneous abortion].
PG  - 976-9
AB  - OBJECTIVE: To investigate the distribution of human leukocyte antigen (HLA)-G and 
      E on human first trimester placenta and its relationship with unexplained 
      recurrent spontaneous abortion (RSA). METHODS: Fifteen women with normal first 
      trimester pregnancy and fifteen patients with RSA were included in this study. In 
      situ hybridization and immunohistochemical staining were employed to detect the 
      mRNA and protein of HLA-G, E in first trimester placenta. RESULTS: The HLA-G, E 
      mRNA were detected in all trophoblasts, including syncytiotrophoblast, villous 
      and extravillous cytotrophoblast. HLA-G protein was only found at extravillous 
      trophoblast by mAb 4H84 specific to HLA-G. The same expression sites were 
      observed for both HLA- E protein and its mRNA. The expression of HLA-G, E mRNA in 
      the RSA group were much lower than those in the control group. The HLA-G, E 
      protein were also expressed at low level in RSA group. CONCLUSION: The 
      inconsistency of the distribution of HLA-G mRNA and protein was probably due to 
      the monoclone antibody 4H84. There is strong correlation between lack of the mRNA 
      and protein expression of HLA-G, E found in the trophoblasts at the 
      fetal-maternal interface and RSA.
FAU - Peng, Bing
AU  - Peng B
AD  - Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan 
      University, Chengdu 610041, China.
FAU - Zhang, Li
AU  - Zhang L
FAU - Xing, Ai-Yun
AU  - Xing AY
FAU - Hu, Min
AU  - Hu M
FAU - Liu, Shu-yun
AU  - Liu SY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Abortion, Habitual/*immunology
MH  - Adult
MH  - Female
MH  - HLA Antigens/genetics/*metabolism
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/genetics/*metabolism
MH  - Humans
MH  - Placenta/cytology/*immunology
MH  - Pregnancy
MH  - Pregnancy Trimester, First
MH  - RNA, Messenger/genetics/metabolism
MH  - Trophoblasts/immunology
MH  - HLA-E Antigens
EDAT- 2009/03/04 09:00
MHDA- 2010/03/03 06:00
CRDT- 2009/03/04 09:00
PHST- 2009/03/04 09:00 [entrez]
PHST- 2009/03/04 09:00 [pubmed]
PHST- 2010/03/03 06:00 [medline]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Nov;39(6):976-9.