PMID- 19254248
OWN - NLM
STAT- MEDLINE
DCOM- 20090529
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 73
IP  - 3
DP  - 2009 Mar
TI  - Major histocompatibility complex class II (DRB1*, DQA1*, and DQB1*) and DRB1*04 
      subtypes' associations of Hashimoto's thyroiditis in a Greek population.
PG  - 199-205
LID - 10.1111/j.1399-0039.2008.01182.x [doi]
AB  - Hashimoto's thyroiditis (HT) is an autoimmune disease resulting from complex 
      interactions between genetic and environmental factors. The disease is associated 
      with certain human leukocyte antigen (HLA) class II alleles in various 
      populations. We aimed to determine in this study, for the first time in a Greek 
      population, the association of HLA-DRB1*, -DQA1*, and -DQB1* alleles with HT. 
      HLA-DRB1*, -DQA1*, and -DQB1* alleles' and -DRB1*04 subtypes' distribution was 
      evaluated in 125 patients with HT and in 500 healthy control individuals by using 
      a DNA-based sequence-specific primer method. Chi(_)squared tests and Bonferroni 
      correction method were applied in the statistical analysis of the data. 
      Significantly higher frequency of DRB1*04 (24.8% vs 7.7%, P < 0.0001) was 
      observed in HT patients, while HLA-DRB1*07 was significantly decreased (2.8% vs 
      7.9%, P < 0.05). HLA-DRB1*04 subtyping showed a significant increase of DRB1*0405 
      (21% vs 7.8%, P < 0.0001) in HT patients. Also significant high frequencies of 
      DQB1*0201 (14.8% vs 8.2%, P < 0.001), DQB1*0302 (18.8% vs 7.0%, P < 0.0001), and 
      DQA1*0301 (25.6% vs 7.8%, P < 0.0001) were recorded in the patient group. 
      Conducting the first research of this kind in a Greek population, our study tries 
      to provide an evaluation of the prevalence of HT relating to HLA-DRB1*0405, and 
      we report a relative risk of 2.7 for HT in a Greek population.
FAU - Kokaraki, G
AU  - Kokaraki G
AD  - Department of Genetics, Development & Molecular Biology, Faculty of Sciences, 
      School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece. 
      gioylako@yahoo.gr
FAU - Daniilidis, M
AU  - Daniilidis M
FAU - Yiangou, M
AU  - Yiangou M
FAU - Arsenakis, M
AU  - Arsenakis M
FAU - Karyotis, N
AU  - Karyotis N
FAU - Tsilipakou, M
AU  - Tsilipakou M
FAU - Fleva, A
AU  - Fleva A
FAU - Gerofotis, A
AU  - Gerofotis A
FAU - Karadani, N
AU  - Karadani N
FAU - Yovos, J G
AU  - Yovos JG
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04 antigen)
SB  - IM
MH  - Adult
MH  - Female
MH  - Genotype
MH  - Greece
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Hashimoto Disease/*genetics/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - White People/genetics
EDAT- 2009/03/04 09:00
MHDA- 2009/05/30 09:00
CRDT- 2009/03/04 09:00
PHST- 2009/03/04 09:00 [entrez]
PHST- 2009/03/04 09:00 [pubmed]
PHST- 2009/05/30 09:00 [medline]
AID - TAN1182 [pii]
AID - 10.1111/j.1399-0039.2008.01182.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2009 Mar;73(3):199-205. doi: 10.1111/j.1399-0039.2008.01182.x.