PMID- 19254257
OWN - NLM
STAT- MEDLINE
DCOM- 20090529
LR  - 20090303
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 73
IP  - 3
DP  - 2009 Mar
TI  - Allelic distribution and the effect of haplotype combination for HLA type II loci 
      in the celiac disease population of the Valencian community (Spain).
PG  - 255-61
LID - 10.1111/j.1399-0039.2008.01191.x [doi]
AB  - The association between human leukocyte antigen (HLA) class II antigens and 
      celiac disease (CD) was analyzed in a Spanish population. No association with 
      DRB1*04 and DQB1*0302 was noted. The main associated haplotype (70.8%) was 
      DRB1*03-DQB1*0201-DQA1*0501(DR3-DQ2), followed by DRB1*07-DQB1*0202-DQA1*0201 
      (DR7-DQ2) haplotype, which is associated with DRB1*11-DQB1*0301-DQA1*0505 
      (DR11-DQ7). The combinations of DR3-DQ2 with DR7-DQ2, and DR7-DQ2 with DR11-DQ7, 
      present a twofold risk compared with each haplotype in homozygosis. An 
      independence test in DR3-DQ2 haplotype found that association with CD was 
      attributable to the whole haplotype, but for DR7-DQ2 was secondary to DQB1/DQA1. 
      There is no need of a double gene dosage to increase the risk. CD-associated 
      alleles typing demonstrates a very high negative predictive value to exclude CD 
      in risk groups.
FAU - Donat, E
AU  - Donat E
AD  - Gastroenterology Unit, La Fe Children's Hospital, Valencia, Spain. 
      donat_est@gva.es
FAU - Planelles, D
AU  - Planelles D
FAU - Capilla-Villanueva, A
AU  - Capilla-Villanueva A
FAU - Montoro, J A
AU  - Montoro JA
FAU - Palau, F
AU  - Palau F
FAU - Ribes-Koninckx, C
AU  - Ribes-Koninckx C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-D Antigens)
SB  - IM
MH  - *Alleles
MH  - Celiac Disease/genetics
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-D Antigens/*genetics
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Population Groups
MH  - Spain
EDAT- 2009/03/04 09:00
MHDA- 2009/05/30 09:00
CRDT- 2009/03/04 09:00
PHST- 2009/03/04 09:00 [entrez]
PHST- 2009/03/04 09:00 [pubmed]
PHST- 2009/05/30 09:00 [medline]
AID - TAN1191 [pii]
AID - 10.1111/j.1399-0039.2008.01191.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2009 Mar;73(3):255-61. doi: 10.1111/j.1399-0039.2008.01191.x.