PMID- 19254258
OWN - NLM
STAT- MEDLINE
DCOM- 20090529
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 73
IP  - 3
DP  - 2009 Mar
TI  - HLA class I allele and haplotype diversity in Ugandans supports the presence of a 
      major east African genetic cluster.
PG  - 262-9
LID - 10.1111/j.1399-0039.2008.01192.x [doi]
AB  - The objective of this study was to characterize the class I human leukocyte 
      antigen (HLA) genetic composition of the Ugandan population to better define its 
      relationship with other African groups. Samples from 175 individuals from Kampala 
      (Uganda) were subjected to class I HLA-A, -B, and -C sequence-based typing. The 
      high concordance between the major alleles and haplotypes found in the current 
      and Kenyan populations and interpopulation genetic distance analysis strongly 
      supported the presence of an East African cluster that contained the current 
      Ugandan population along with Kenyan Luo and Nandi populations. The congruence of 
      major alleles in different populations would permit consideration of East Africa 
      as an integrated setting when designing and evaluating much needed malaria, 
      tuberculosis, and AIDS vaccines.
FAU - Kijak, G H
AU  - Kijak GH
AD  - Division of Retrovirology, US Military HIV Research Program/Henry M. Jackson 
      Foundation, Rockville, MD 20850, USA. gkijak@hivresearch.org
FAU - Walsh, A M
AU  - Walsh AM
FAU - Koehler, R N
AU  - Koehler RN
FAU - Moqueet, N
AU  - Moqueet N
FAU - Eller, L A
AU  - Eller LA
FAU - Eller, M
AU  - Eller M
FAU - Currier, J R
AU  - Currier JR
FAU - Wang, Z
AU  - Wang Z
FAU - Wabwire-Mangen, F
AU  - Wabwire-Mangen F
FAU - Kibuuka, H N
AU  - Kibuuka HN
FAU - Michael, N L
AU  - Michael NL
FAU - Robb, M L
AU  - Robb ML
FAU - McCutchan, F E
AU  - McCutchan FE
LA  - eng
GR  - 2 Y1-AI-2642-11/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - *Alleles
MH  - Black People/*genetics
MH  - Haplotypes/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Multigene Family/*genetics
MH  - Uganda
EDAT- 2009/03/04 09:00
MHDA- 2009/05/30 09:00
CRDT- 2009/03/04 09:00
PHST- 2009/03/04 09:00 [entrez]
PHST- 2009/03/04 09:00 [pubmed]
PHST- 2009/05/30 09:00 [medline]
AID - TAN1192 [pii]
AID - 10.1111/j.1399-0039.2008.01192.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2009 Mar;73(3):262-9. doi: 10.1111/j.1399-0039.2008.01192.x.