PMID- 19254259
OWN - NLM
STAT- MEDLINE
DCOM- 20090529
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 73
IP  - 3
DP  - 2009 Mar
TI  - Ethnic variation of the HLA-G*0105N allele in two Chinese populations.
PG  - 270-4
LID - 10.1111/j.1399-0039.2008.01196.x [doi]
AB  - Unlike high polymorphic classical human leukocyte antigen (HLA) class I 
      molecules, the genetic polymorphism of HLA-G is very limited. However, the 
      prevalence of HLA-G alleles among different ethnic populations varied 
      dramatically. The HLA-G null allele (HLA-G*0105N) is defined by a cytosine 
      deletion (Delta C) at position 1597 in exon 3, which disrupts the reading frame 
      and alters the expression of HLA-G proteins. The HLA-G*0105N allelic frequency 
      was investigated in previous studies and possible roles were addressed. In the 
      current study, a total of 310 Chinese Han and 260 Chinese She ethnic minority 
      population had been genotyped for the G*0105N polymorphism. Marked difference was 
      observed that the G*0105N allelic frequency in Chinese Han was 1.61%, while no 
      copy of the null allele was observed in the Chinese She minority population (P(c) 
      = 0.0073). Data also revealed that no homozygote of HLA-G*0105N allele exists in 
      this Chinese Han population. Furthermore, significant difference was found for 
      the frequencies of HLA-G*0105N both in Chinese Han and in Chinese She populations 
      when compared with other ethnic populations. Taken together, our results 
      indicated that ethnic variation of the HLA-G*0105N polymorphism among different 
      ethnic populations is possibly the result of evolution. However, the advantages 
      of the selection of this allele are necessary to be further investigated.
FAU - Lin, A
AU  - Lin A
AD  - Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical 
      College, Linhai, Zhejiang, China.
FAU - Li, M
AU  - Li M
FAU - Xu, D-P
AU  - Xu DP
FAU - Zhang, W-G
AU  - Zhang WG
FAU - Yan, W-H
AU  - Yan WH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (HLA-G*01:05N antigen)
SB  - IM
MH  - *Alleles
MH  - Asian People/*genetics
MH  - China/ethnology
MH  - Genetic Variation
MH  - HLA Antigens/*genetics
MH  - HLA-G Antigens
MH  - Humans
MH  - Polymorphism, Genetic
EDAT- 2009/03/04 09:00
MHDA- 2009/05/30 09:00
CRDT- 2009/03/04 09:00
PHST- 2009/03/04 09:00 [entrez]
PHST- 2009/03/04 09:00 [pubmed]
PHST- 2009/05/30 09:00 [medline]
AID - TAN1196 [pii]
AID - 10.1111/j.1399-0039.2008.01196.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2009 Mar;73(3):270-4. doi: 10.1111/j.1399-0039.2008.01196.x.