PMID- 19254290
OWN - NLM
STAT- MEDLINE
DCOM- 20090609
LR  - 20151119
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 64
IP  - 5
DP  - 2009 May
TI  - Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with 
      total serum IgE.
PG  - 746-53
LID - 10.1111/j.1398-9995.2008.01889.x [doi]
AB  - BACKGROUND: Serum immunoglobulin E (IgE) level is recognized to be under strong 
      genetic control, but the causal and susceptibility genes remain to be identified. 
      We sought to investigate the association between single nucleotide polymorphisms 
      (SNPs) in the Toll-like receptor (TLR) signaling pathway and total serum IgE 
      level. METHODS: A population of 206 patients with severe chronic rhinosinusitis 
      (CRS) was used. Precise phenotyping of patients was accomplished by means of a 
      questionnaire and clinical examination. Blood was drawn for measurement of total 
      serum IgE, as well as DNA extraction. A maximally informative set of SNPs in the 
      TLR1, 2, 3, 4, 6, 9, 10, CD14, MD2, MyD88, IRAK4, and TRAF6 genes were selected 
      and genotyped. Significant findings were replicated in a second independent 
      population of 956 subjects from 227 families with asthma. RESULTS: A total of 97 
      out of 104 SNPs were successfully genotyped. Three SNPs in IRAK4--rs1461567, 
      rs4251513, and rs4251559--were associated with total serum IgE levels (P < 
      0.004). In the replication sample, the same SNPs as well as the same orientation 
      of the risk allele were associated with IgE levels (P < 0.031). CONCLUSIONS: 
      These results demonstrate a clear association between polymorphisms in the IRAK4 
      gene and serum IgE levels in patients with CRS and asthma. IRAK4 may be important 
      in the regulation of IgE levels in patients with inflammatory diseases of the 
      airways.
FAU - Tewfik, M A
AU  - Tewfik MA
AD  - Department of Otolaryngology-Head and Neck Surgery, Montreal General Hospital, 
      McGill University, Montreal, Canada.
FAU - Bosse, Y
AU  - Bosse Y
FAU - Lemire, M
AU  - Lemire M
FAU - Hudson, T J
AU  - Hudson TJ
FAU - Vallee-Smejda, S
AU  - Vallee-Smejda S
FAU - Al-Shemari, H
AU  - Al-Shemari H
FAU - Laprise, C
AU  - Laprise C
FAU - Desrosiers, M
AU  - Desrosiers M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090227
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 2.7.11.1 (IRAK4 protein, human)
RN  - EC 2.7.11.1 (Interleukin-1 Receptor-Associated Kinases)
SB  - IM
MH  - Adult
MH  - Chronic Disease
MH  - Cross-Sectional Studies
MH  - Female
MH  - Gene Frequency/*genetics/immunology
MH  - Genotype
MH  - Humans
MH  - Hypersensitivity/*genetics/immunology
MH  - Immunoglobulin E/*blood
MH  - Interleukin-1 Receptor-Associated Kinases/*genetics/immunology
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Surveys and Questionnaires
EDAT- 2009/03/04 09:00
MHDA- 2009/06/10 09:00
CRDT- 2009/03/04 09:00
PHST- 2009/03/04 09:00 [entrez]
PHST- 2009/03/04 09:00 [pubmed]
PHST- 2009/06/10 09:00 [medline]
AID - ALL1889 [pii]
AID - 10.1111/j.1398-9995.2008.01889.x [doi]
PST - ppublish
SO  - Allergy. 2009 May;64(5):746-53. doi: 10.1111/j.1398-9995.2008.01889.x. Epub 2009 
      Feb 27.