PMID- 19256760
OWN - NLM
STAT- MEDLINE
DCOM- 20090528
LR  - 20170308
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 9
IP  - 4
DP  - 2008 Oct-Dec
TI  - Molecular cytogenetic analysis of urothelial carcinomas using urine samples.
PG  - 687-90
AB  - Urinary cells obtained from voided urine specimens of 46 patients with urothelial 
      carcinomas (UCs) and 10 normal individuals were analyzed with 3 different 
      centromeric fluorescence in situ hybridization (FISH) probes. The overall 
      sensitivity of cytology was 48.9% compared to 95.7%with the FISH technique. The 
      minimum values were found for stage Ta and grade 1 (90.5 and 89.4) and 
      sensitivity of FISH in other stages and grades was 100%. Chromosome 3 
      demonstrated the most frequent chromosomal abnormality in all samples (43%), 
      followed by chromosome 17 (32%) and chromosome 7 (25%). There was a statistically 
      significant association between the number of cell abnormalities in chromosome 17 
      and the tumour stage (p value=0.02). No relationship was found between the type 
      of chromosomal abnormality and grade. Thus feasibility and reliability of a FISH 
      based approach was confirmed for detection of UC in urine samples.
FAU - Ayati, M
AU  - Ayati M
AD  - Department of Urooncology, Imam Khomeini Hospital, Tehran, Iran.
FAU - Tousi, V Najjaran
AU  - Tousi VN
FAU - Sabokba, T
AU  - Sabokba T
FAU - Vaziri-Nasab, H
AU  - Vaziri-Nasab H
FAU - Mehrkhani, F
AU  - Mehrkhani F
FAU - Jamshidian, H
AU  - Jamshidian H
FAU - Dastan, J
AU  - Dastan J
FAU - Mosavi-Jarrahi, A R
AU  - Mosavi-Jarrahi AR
FAU - Ghaffari, S R
AU  - Ghaffari SR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Transitional Cell/*genetics/*urine
MH  - Case-Control Studies
MH  - Chromosome Aberrations
MH  - Chromosomes, Human, Pair 17
MH  - Chromosomes, Human, Pair 3
MH  - Chromosomes, Human, Pair 7
MH  - Cytodiagnosis/methods
MH  - Cytogenetic Analysis/*methods
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Sampling Studies
MH  - Sensitivity and Specificity
MH  - Urinary Bladder Neoplasms/*genetics/*urine
MH  - Urine/*cytology
EDAT- 2009/03/05 09:00
MHDA- 2009/05/29 09:00
CRDT- 2009/03/05 09:00
PHST- 2009/03/05 09:00 [entrez]
PHST- 2009/03/05 09:00 [pubmed]
PHST- 2009/05/29 09:00 [medline]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2008 Oct-Dec;9(4):687-90.